Background: Bladder cancer ranks tenth in worldwide cancer incidence. With 550,000 newly diagnosed cases in 2018. It is the 7th most common cancer in men and the 17th most common cancer in women. In Egypt the incidence rate of cancer bladder in (2008-2011) 6.94% in both sexes and (10.7%) among men. Aim of the Work: To study the prognostic value of PD-L1 tissue tumoral expression in Egyptian patients with epithelial bladder cancer and its correlation with the different clinicopathological parameters. Patients and Methods: This is a prospective, single arm, cross sectional study which was carried on newly diagnosed 30 patients with epithelial urinary bladder cancer were identified with follow up for 2 years from (Aug 2017-Sep 2019). At both Clinical Oncology and Nuclear Medicine department Ain Shams university Hospital and
Nasser Institute Cancer Centre for researches and treatment (NICC). Results: In our study we confirmed that high PD-L1 expression is correlated with prognosis, as patients with high PD-L1tumor expression cells had lower DFS and OS. The tumor PD-L1 over expression had high significant impact on PFS where patients who had PD-L1overexpression had mean 7.2 months compared to 11.4 months in patients who had low tumor PD-L1 expression (P value=0.004). also had significant impact on OS where patients who had high tumor PD-L1 over expression had mean OS 9.633 months
compared to 12.00 months in patients who had low tumor PD-L1 expression, (P value= 0.047). Conclusion: Our study concluded that high expression of PDL1 was associated with low PFS and OS and worst prognosis.