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269947

PROTECTIVE EFFECT OF N-ACEETYLCYSTEIN AGAINST OXIDATIVE STRESS IN RELATION TO SEMEN CHARACTERISTICS IN NEW ZEALAND WHITE RABBITS

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Physiology

Abstract

SUMMARY
 
A total of 15 mature New Zealand White (NZW) rabbit bucks, aged 6-8 months, weighing about 3.5 Kg were divided into three equal groups, control group (G1) that injected subcutaneously with saline solution, while bucks in  G2 and G3 were injected subcutaneously with 50 and 100 mg NAC / kg body weight, respectively for seven consecutive days. Blood samples were collected at days 8and day 47, and semen characteristics were evaluated at day 48. The results revealed that there was a positive effect of NAC on antioxidant status through its obvious impact on MDA level that continuously decreased, in G3, from 6.10 to 3.58 nmol/ml, from zero day-to-day 47.While, G1 recorded continuous increase. Additionally, NAC injection with the dose of 100 mg/kg BW succeeded in elevating catalase activity that elevated from 329.8 to 372.4 U/L) on the 8th day compared to its levels in zero day. Moreover, H2O2 was insignificantly declined and this decline continued until the day 47 in G3 (declined from 0.093, at zero day to 0.083 mmol/L, at day 47) with stable level in G2 (0.098 mmol/L, at 8th and 47 days). No side effects of the NAC injections were detected as confirmed by normal activity of liver enzymes (ALT and AST) in rabbits. The same trend was noticed for kidney functions. Additionally, an enhancement of semen characteristics due to NAC injections was observed, especially in G3.
 

DOI

10.21608/ejap.2022.147551.1043

Keywords

Keywords: Rabbit, Bucks, N-acetylcysteine, antioxidants, Liver and kidney functions, semen characteristics

Authors

First Name

Samah

Last Name

Abdel-Rahman

MiddleName

Mohamed

Affiliation

Animal Production Research Institute -Agricultural Research Institute

Email

samah.abdelrahman@yahoo.com

City

Giza

Orcid

-

First Name

Gamal

Last Name

Ashour

MiddleName

-

Affiliation

Animal Production Department, Faculty of Agriculture, Cairo University

Email

gashour57@yahoo.com

City

-

Orcid

0000-0002-5997-979X

First Name

Noha

Last Name

Abd El-Azeem

MiddleName

M.

Affiliation

Animal Production Research Institute, Agricultural Research Center

Email

-

City

-

Orcid

-

First Name

Safaa

Last Name

Barakat

MiddleName

A.

Affiliation

Animal Production Research Institute, Agricultural Research Center

Email

-

City

-

Orcid

-

First Name

Dessouki

Last Name

M

MiddleName

S.H.

Affiliation

Animal Production Department, Faculty of Agriculture, Cairo University

Email

-

City

-

Orcid

-

First Name

Mehaisen

Last Name

G.

MiddleName

M.K

Affiliation

Animal Production Department, Faculty of Agriculture, Cairo University

Email

-

City

-

Orcid

-

Volume

59

Article Issue

3

Related Issue

37650

Issue Date

2022-11-01

Receive Date

2022-06-28

Publish Date

2022-11-01

Page Start

121

Page End

130

Print ISSN

0302-4520

Online ISSN

2735-3028

Article File

EJAP_Volume 59_Issue 3_Pages 121-130.pdf

PDF . 884.4kB

Link

https://ejap.journals.ekb.eg/article_269947.html

Detail API

https://ejap.journals.ekb.eg/service?article_code=269947

Order

4

Type

Original Article

Type Code

1,298

Publication Type

Journal

Publication Title

Egyptian Journal of Animal Production

Publication Link

https://ejap.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023