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224567

ULTRASTRUCTURAL CHANGES OF KIDNEY INDUCED BY COPPER NANOPARTICLES AND THE THERAPEUTIC ROLE OF VITAMINS E AND C AGAINST CYTOTOXICITY

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Last updated: 04 Jan 2025

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Abstract

The ability of nanoparticles as anti-bacterial materials has led to their widespread application in many health products. However, there are many concerns about the exposure of individuals to these particles, addressed the cellular effects caused by copper nanoparticles on the kidneys using transmission electron microscopy, and investigating the potential therapeutic role of vitamin E and C against the toxicity of copper nanoparticles and their cellular harmful effects.
The study used 56 rats (Rattus norvegicus) divided into seven groups and dosed over a month with copper nanoparticles and then dosed for another month with both vitamins E and C, either alone or together, the results showed that the animals of the groups that were treated with copper nanoparticles showed micro-structural changes in the kidneys. Changes were found in the renal tissue at the level of the podocytes forming the endothelial cells in the visceral layer of the renal glomeruli. It was also observed that mitochondria were affected in the epithelial cells of the Proximal convoluted tubules. In addition to an increase in the number of lysosomes and cytoplasmic vacuoles. The effective therapeutic role of vitamin C, E has been shown in improving the size and number of organelles and returning them to their almost normal state. The study recommends the need to use vitamins C and E at a dose of 250 mg/kg/day, which showed a positive role in reducing the toxicity of copper nanoparticles.

DOI

10.21608/ejap.2022.115684.1033

Keywords

Copper nanoparticles, kidney, Cellular Effects, Vitamins C and E

Authors

First Name

Yahya

Last Name

Shotop

MiddleName

M.

Affiliation

King Saud University- College of Science

Email

yshotop@gmail.com

City

Riyadh

Orcid

0000-0001-8116-2957

First Name

Ibrahim

Last Name

Al-Suwiti

MiddleName

N.

Affiliation

King Saud University- Colleg of Science

Email

ibrahm221@hotmail.com

City

Riyadh

Orcid

-

Volume

59

Article Issue

1

Related Issue

32132

Issue Date

2022-02-01

Receive Date

2022-01-20

Publish Date

2022-02-01

Page Start

35

Page End

42

Print ISSN

0302-4520

Online ISSN

2735-3028

Article File

EJAP_Volume 59_Issue 1_Pages 35-42.pdf

PDF . 2.0MB

Link

https://ejap.journals.ekb.eg/article_224567.html

Detail API

https://ejap.journals.ekb.eg/service?article_code=224567

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5

Type

Original Article

Type Code

1,298

Publication Type

Journal

Publication Title

Egyptian Journal of Animal Production

Publication Link

https://ejap.journals.ekb.eg/

MainTitle

ULTRASTRUCTURAL CHANGES OF KIDNEY INDUCED BY COPPER NANOPARTICLES AND THE THERAPEUTIC ROLE OF VITAMINS E AND C AGAINST CYTOTOXICITY

Details

Type

Article

Created At

22 Jan 2023