Acute respiratory distress syndrome (ARDS) is recognized to be accompanied by severe lung and heart complications. This study aimed to demonstrate the efficacy of Calcium hypochlorite in cyclophosphamide (CP)-induced pulmonary and cardiac injury in mice. The CP-induced toxicity in the lung and heart is like that caused by ARDS. Calcium hypochlorite significantly attenuated doth lung and heart functionality and significantly reduced the CP-induced perivascular inflammation, congestion of blood vessels, and severe morphological changes of the alveolar wall. It also exerts anti-inflammatory and antioxidant effects on CP-induced pulmonary and heart toxicity. Given these results, calcium hypochlorite successfully ameliorates ARDS symptoms rendering calcium hypochlorite to be a promising agent to be tested in models of pneumonia caused by bacterial or viral infections, including those of acute respiratory distress syndrome (ARDS).