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198090

Evaluation of diagnostic performances of leptin and vitamin D for colorectal cancer diagnosis and follow-up

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Last updated: 25 Dec 2024

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Abstract

Globally, colorectal cancer (CRC) is one of the most often diagnosed solid tumors, with a significant death and morbidity rate. CRC biomarkers are desperately needed for early detection. Traditional CRC tumor markers do not have the best diagnostic performance. The levels of leptin and vitamin D were evaluated. CRC patients before treatment (n=16), CRC patients after treatment (n=14), and 20 patients with benign tumors were included in this case-control study. ELISA was used to determine the levels of traditional tumor markers (CA19.9 and CEA) as well as candidate markers (leptin and vitamin D). Using area receiver-operating characteristic analysis (AUC), the diagnostic performance of single and combination markers was assessed (ROC). The levels of CEA and CA 19.9 in the three groups studied were not significantly different. Vitamin D and leptin were significantly decreased (p= 0.03 and p= 0.02; respectively) in CRC patients than after benign patients. A novel combination, based on the combination of vitamin D and leptin was developed for CRC diagnosis using stepwise multivariate discriminant analysis (MDA). The combination can be represented as = (4.65 – vitamin D ((ng/ml)) × 0.009 + Leptin (ng/ml) × 0.441). AUCs were reported when leptin was used as a single biomarker for distinguishing CRC from benign (0.78) and non-treated CRC from treated CRC (0.67). When leptin and vitamin D were combined, the AUCs increased to 0.84 and0.72, respectively. Conclusion: Leptin and vitamin D were shown to be promising diagnostic and follow-up indicators for CRC in our investigation.

DOI

10.21608/jbaar.2021.198090

Keywords

Colorectal cancer (CRC), leptin, Vitamin D, ELISA

Authors

First Name

Manar

Last Name

Fouda

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Sara

Last Name

Mekkawy

MiddleName

A.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mariam

Last Name

Ghabour

MiddleName

T.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Radwa

Last Name

Othman

MiddleName

E.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Nayera

Last Name

Ahmed

MiddleName

A.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Nour

Last Name

Habbib

MiddleName

A.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Salsabeel

Last Name

Elkholey

MiddleName

A.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Rahma

Last Name

Soliman

MiddleName

M.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Maria

Last Name

Fouad

MiddleName

C.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Ellen

Last Name

Ayad

MiddleName

Y.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mayar

Last Name

Shaqran

MiddleName

A.

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mariam

Last Name

Mohamed

MiddleName

I

Affiliation

Molecular Biotechnology Program, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Rokaia

Last Name

Aljarwani

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Aboul-Enein

MiddleName

-

Affiliation

Clinical Pathology Department, National Cancer Institute, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Omran

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt

Email

drmmomran@science.helwan.edu.eg

City

-

Orcid

-

Volume

7

Article Issue

3

Related Issue

28360

Issue Date

2021-09-01

Receive Date

2021-07-25

Publish Date

2021-09-28

Page Start

108

Page End

115

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 7_Issue 3_Pages 108-115.pdf

PDF . 351.9kB

Link

https://jbaar.journals.ekb.eg/article_198090.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=198090

Order

2

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Evaluation of diagnostic performances of leptin and vitamin D for colorectal cancer diagnosis and follow-up

Details

Type

Article

Created At

22 Jan 2023