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154438

Comparison between glypican-3 and alpha-fetoprotein in discrimination of hepatocellular carcinoma from cirrhotic patients

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Last updated: 25 Dec 2024

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Abstract

Background: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Liver cirrhosis progression could be a consequence of developing HCC. Although alpha-fetoprotein (AFP) is widely used as, a marker for the detection of HCC, but it has poor sensitivity. Objective: Evaluate the diagnostic power of serum AFP and Glypican-3 (GPC3) as biomarkers of the development of HCC. Subjects and Methods: A total of 182 patients, 110 patients with HCC, and 72 patients with liver cirrhosis were included. AFP and GPC3 were determined using ELISA. The diagnostic power was evaluated using Area under Roc curve (AUC). Results: levels of AFP and GPC3 in sera of HCC patients were higher than in those with liver cirrhosis (p < 0.0001). AFP had Area under curve (AUC) = 0.772 with sensitivity 39.1%, specificity 97.2%, positive predictive value (PPV) 97.7%, negative predictive value (NPV) 34.3% and efficiency 53.4% while GPC3 had AUC=0.841 yielded sensitivity 76.4%, specificity 86.1%, PPV 94.4%, NPV 64.3% and efficiency 78.8%. There was significant weak correlation (r = 0.241; P < 0.001) between AFP and GPC3. Conclusions: GPC3 is a good marker for HCC diagnosis. Therefore, GPC3 may be more useful than AFP in differentiating HCC from cirrhotic patients.

DOI

10.21608/jbaar.2018.154438

Keywords

AFP, Glypican-3, Liver cirrhosis, HCC, Blood markers, Diagnosis

Authors

First Name

Abdelfattah

Last Name

Attallah

MiddleName

M.

Affiliation

Research &amp; Development Department, Biotechnology Research Center, New Damietta, Egypt

Email

amattallah@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Far

MiddleName

Abd El-Hafez

Affiliation

Chemistry department, Faculty of Science, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Omran

MiddleName

Mostafa

Affiliation

Chemistry department, Faculty of Science, Helwan University, Helwan, Egypt

Email

drmmomran@yahoo.com

City

-

Orcid

0000-0001-8557-3104

First Name

Aya

Last Name

Saeed

MiddleName

Mohamed

Affiliation

Research & Development Department, Biotechnology Research Center, New Damietta City, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Elbendary

MiddleName

Sayed

Affiliation

Research & Development Department, Biotechnology Research Center, New Damietta City, Egypt

Email

-

City

-

Orcid

-

First Name

Kareem

Last Name

Attallah

MiddleName

Abdelfattah

Affiliation

Research & Development Department, Biotechnology Research Center, New Damietta City, Egypt

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Mari

MiddleName

Farid

Affiliation

Tropical medicine department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

Volume

4

Article Issue

4

Related Issue

22148

Issue Date

2018-12-01

Receive Date

2018-09-22

Publish Date

2018-12-08

Page Start

459

Page End

468

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 4_Issue 4_Pages 459-468.pdf

PDF . 518.2kB

Link

https://jbaar.journals.ekb.eg/article_154438.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=154438

Order

11

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Comparison between glypican-3 and alpha-fetoprotein in discrimination of hepatocellular carcinoma from cirrhotic patients

Details

Type

Article

Created At

22 Jan 2023