This research deals with the effect of pheromones, queen mandibular pheromone one gene expression of brain adult for workers honeybee Apis mellifera, these expressions can explain the response behavior induced by pheromones QMP, the impact of gene expression by affecting the movement of workers A. mellifera in the colony of honeybees in the case of the presence of the Queen. Queen's absence means the lack of workers as a result of the lack of pheromones  (QMP) or the presence of a few compared to the presence of the Queen.  The behavior of workers is linked to the existence of pheromones released by the Queen.