The regional differences in the mix of cancers and diseases provoke many questions regarding the causes that control the susceptibility, in this work, it is proven that behavioral deviance is the main cause for the increased selective disease susceptibility through cross-sectional studies. Theoretically, it is suggested that human leucocyte antigens are a marker for a deviated ancestors, and satellite DNA is an expression to the common-sense and reflects the behavior (The Gene-Behavior Theory), causing increased disease susceptibility if deviated. The conformity approach which used in the human-community theory explains many social and genetic mechanisms, especially, how human-human interactions affect genetic damage/repair.