In the current explanatory study, experimental methods were conducted to anticipate the effect of therapeutic ultrasound irradiation on the liver and kidney of male albino mice. The histopathological studies revealed a convenient apparent aberration. These findings were supported by hematological investigation of complete blood count (CBC), blood enzymes like aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT), alsoCreatinine and Urea levels were detected. The results showed no significant alteration in the physiological function of both liver and kidney.  The level of malondialdehyde (MDA) and total antioxidant contents were carried out. the level of   Glutathione (GST), Superoxide dismutase (SOD) were still in normal ranges.