Background: Logically, successful treatment requires correct diagnosis based on the accuracy, reproducibility, and interpretability of investigations and examinations. The mission of health laboratory services is to provide high-quality services in the right place and at the right time in respect of the needs of patients, the community health staff including not only clinicians but also an epidemiologist and environmental sanitarians. Quality is the degree to which care services influence the probability of optimal patient outcomes." American Medical Association, 1991. Quality is never an accident. Research objective: To assess the quality of results presented by health center laboratories, for diagnosis of S.haematobium in El-Fayoum Governorate. Subjects and methods: A cross-sectional study was carried. This study was carried out in the Ministry of Health Laboratory Centers, in El- Fayoum Governorate. A list of health centers was obtained from the Ministry of Health (MOH). Ten Health Laboratories were included in this study: Two central laboratories (Control Laboratory and Evaluation Laboratory) and eight laboratories in eight centers were chosen randomly from the list, from each laboratory 100 random urine samples were obtained and the total sample size was 1000 urine samples. Results: In all centers, the number of positive cases was lower than that detected by the study except in lab.1 (El-Hadka health center laboratory), it detects one false positive case. The case was had red blood cells in urine. And lab. No.9,(El-Sadeek primary school laboratory), there was no positive cases either by the researcher or the health center laboratories, and the total percentage of positive cases detected by health center laboratories was 67.1 % concerning that detected by the researcher. Conclusion and recommendations: In all health center laboratories the number of positive cases was lower than that detected by the researcher, and the total percentage of positive cases detected by health center laboratories was 67.1 % with that detected by the researcher. So using of Nuclepore membrane filtration technique is important for the diagnosis of S.haematobium and continuous training for health center laboratory staff is very important.