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109753

Effects of propolis on histopathological and immunohistochemical alterations in testes of thyroidectomized rat.

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Last updated: 04 Jan 2025

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Abstract

The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine, are secreted by the thyroid gland which are responsible for the regulation of metabolism in all body tissues. This work aimed to study the histopathological, immunohistochemical and biochemical changes in the adult rat testes after thyroidectomy, in addition to the role of propolis in reducing these changes. Twenty five male Wistar rats were assigned randomly into equal (5) groups; control, sham operated, shamed propolis, thyroidectomized, thyroidectomy treated with propolis. Levels in compare to control the thyroidectomized rats showed significantly decrease in serum T3 and increase in TSH levels. Degeneration and increase in the seminiferous tubules lumen also noticed. Immunohistochemical results showed a remarkable reduction of proliferating cell nuclear antigen (PCNA) and Ki-67 in spermatogonia of thyroidectomized rat testes as compared with control group. The results revealed that, propolis has an ameroliating role on thyroidectomized rats testes by decreasing damage.

DOI

10.21608/jbaar.2016.109753

Keywords

Thyroidectomy, testes, Propolis, PCNA, Ki67, Immunohistochemistry

Authors

First Name

Ezar

Last Name

Hafez

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

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Volume

2

Article Issue

12

Related Issue

16669

Issue Date

2016-12-01

Receive Date

2016-11-11

Publish Date

2016-12-23

Page Start

764

Page End

770

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 12_Pages 764-770.pdf

PDF . 884.2kB

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https://jbaar.journals.ekb.eg/article_109753.html

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https://jbaar.journals.ekb.eg/service?article_code=109753

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Effects of propolis on histopathological and immunohistochemical alterations in testes of thyroidectomized rat.

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Article

Created At

22 Jan 2023