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109751

Effects of L-carnitine and Ginkgo biloba on Pentylentetrazol-induced liver damage and oxidative stress in rats.

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Last updated: 25 Dec 2024

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Abstract

Pentylentetrazol (PTZ) kindling is an acknowledged models for epilepsy. The current study aimed to determine the possible protective and ameliorative effects of Lcarnitine and Ginkgo biloba (GB) against PTZ induced liver injury and oxidative stress in male rats. A total of 80 male albino rats were equally divided into eight groups; 1st group was the control; 2nd and 3rd were GB and Lcarnitine groups, respectively; 4th group was pentylenetetrazole rat group and the 5th and 6th groups were pre and post treated PTZ with L-carnitine groups respectively; the 7th and 8th groups were pre and post treated PTZ with GB respectively. Serum ALT, AST, ALP and MDA in liver tissue were significant increase in PTZ group when compare with control, while serum ALB and CAT, SOD, GST and TAC in liver tissue were significant decrease in PTZ group when compare with control. On other hand post and pre-treatment with L-carnitine and GB improved these parameters. Our results revealed that the treatment with L-carnitine improved these parameters more than GB and the results of post treatment were better than pre-treatment.

DOI

10.21608/jbaar.2016.109751

Keywords

Pentylentetrazol, L-carnitine, Ginkgo biloba, Liver functions, Oxidative Stress

Authors

First Name

Reda M.

Last Name

Fekry

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Egypt

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Orcid

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First Name

Akaber TH

Last Name

Keshta

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Egypt

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Orcid

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First Name

Wafaa K.

Last Name

Abo-Ghaneima

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Egypt

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City

-

Orcid

-

First Name

Ehab

Last Name

Tousson

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt

Email

toussonehab@yahoo.com

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Orcid

-

Volume

2

Article Issue

12

Related Issue

16669

Issue Date

2016-12-01

Receive Date

2016-11-05

Publish Date

2016-12-21

Page Start

753

Page End

757

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 12_Pages 753-757.pdf

PDF . 199.6kB

Link

https://jbaar.journals.ekb.eg/article_109751.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=109751

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2

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Effects of L-carnitine and Ginkgo biloba on Pentylentetrazol-induced liver damage and oxidative stress in rats.

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Article

Created At

22 Jan 2023