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109502

Efficacy of saffron extract and fenugreek seeds supplementation on liver of streptozotocin induced diabetic rats

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Last updated: 25 Dec 2024

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Abstract

The present study aimed to investigate the possible hypoglycemic and hepatoprotective effects of saffron extract (100mg/kg b.wt) and fenugreek supplementation (1.4 g/day/kg b.wt) in STZ- induced diabetic rats at biochemical, histological, histochemical and ultrastructural levels. The results indicated that a single dose of STZ (50 mg /kg b wt, i.p) caused a significant increase in serum and liver total lipids, total cholesterol and triglyceride as well as serum low density and a very low density lipoprotein, accompanied by an increase in serum glucose level and oxidative stress marker, malondialdehyde and hydrogen peroxide level as well as serum aspartate and alanine aminotransferase activities. The results also reported a significant decrease in the high density lipoprotein, serum and liver total protein, serum albumin and globulin contents and A/G ratio, as well as a significant decrease in serum insulin level and the liver enzyme activities and the hepatic glutathione content. Histologically, STZ treated group showed degenerative changes in the pancreas and alteration in the structural integrity of the hepatocytes and their intracellular organelles. Histochemically, liver sections of STZ treated animals displayed marked decrease in the glycogen and total protein contents. On the other hand, the intake of saffron or fenugreek minimize the disturbance observed in the most tested parameters resulted from STZ administration and improve the liver structure and functions. Finally, it can be concluded that the intake of natural product such as saffron or fenugreek may be effective in reducing the diabetic liver injury induced by streptozotocin and the fenugreek supplementation showed more amelioration than saffron extract.

DOI

10.21608/jbaar.2016.109502

Keywords

fenugreek, histochemistry, histopathology, Liver, Saffron, streptozotocin, Ultrastructure

Authors

First Name

Doaa A.

Last Name

Ali

MiddleName

-

Affiliation

Zoology Department - Faculty of Science - Mansoura University, Mansoura, Egypt.

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Orcid

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First Name

Hanaa

Last Name

Serag

MiddleName

-

Affiliation

Zoology Department - Faculty of Science - Mansoura University, Mansoura, Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdeen

MiddleName

-

Affiliation

Zoology Department - Faculty of Science - Mansoura University, Mansoura, Egypt.

Email

-

City

-

Orcid

-

First Name

Radwa

Last Name

Refaat

MiddleName

-

Affiliation

Zoology Department - Faculty of Science - Mansoura University, Mansoura, Egypt.

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-

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Orcid

-

Volume

2

Article Issue

11

Related Issue

16644

Issue Date

2016-11-01

Receive Date

2016-10-11

Publish Date

2016-11-21

Page Start

707

Page End

722

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 11_Pages 707-722.pdf

PDF . 1.7MB

Link

https://jbaar.journals.ekb.eg/article_109502.html

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https://jbaar.journals.ekb.eg/service?article_code=109502

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Efficacy of saffron extract and fenugreek seeds supplementation on liver of streptozotocin induced diabetic rats

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Article

Created At

22 Jan 2023