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109495

Protective effect of garlic on methyl ethyl ketone-induced biochemical changes in male rabbits.

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Last updated: 25 Dec 2024

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Abstract

The present study evaluated the effect of inhalation of methyl ethyl ketone (MEK) on biochemical parameters of rabbits and the possible protective role of garlic aqueous extract. Animals were divided into 4 groups. Group 1 served as controls, group2 given garlic aqueous extract (0.2mg/ml, for a week), group 3 were inhaled (MEK) (500 ppm for 3 minutes daily for 4 weeks), group 4 inhaled MEK for 4 weeks and given garlic for another week. The results showed that exposing animals to MEK induced significant decrease in RBCs count, hemoglobin, hematocrit percentage and blood platelets. On the other hand, the WBCs count was increased. Triglycerides, cholesterol and transaminases (ALT and AST) were increased in the sera of treated rabbits. Rabbits inhaled MEK for two weeks and given garlic aqueous extract for another week showed an improvement of the hematological and biochemical parameters. It is concluded from the present results that garlic aqueous extract modulated toxicity of MEK and this may be attributed to the antioxidant activity of garlic constituents

DOI

10.21608/jbaar.2016.109495

Keywords

MEK, Rabbits, hematology, transaminases, Garlic, antioxidants

Authors

First Name

Zuhair Y.

Last Name

Al-Sahhaf

MiddleName

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Affiliation

Department of Biology Faculty of Applied Sciences, Umm Al Qura University, Makkah, Saudi Arabia

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Volume

2

Article Issue

10

Related Issue

16640

Issue Date

2016-10-01

Receive Date

2016-09-15

Publish Date

2016-10-25

Page Start

695

Page End

699

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 10_Pages 695-699.pdf

PDF . 472.7kB

Link

https://jbaar.journals.ekb.eg/article_109495.html

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https://jbaar.journals.ekb.eg/service?article_code=109495

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5

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Protective effect of garlic on methyl ethyl ketone-induced biochemical changes in male rabbits.

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Article

Created At

22 Jan 2023