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109494

Modulation of boldenone induced hepatic and renal toxicity by Moringa oleiferaas in albino rats.

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Last updated: 25 Dec 2024

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Abstract

Boldenone is an anabolic androgenic steroid and synthetic derivative of testosterone that was originally developed for veterinary use. Its use is very spread on veterinary medicine because its ability to increase protein synthesis. The aim of this study is to show the toxic effect in liver and kidney caused after the intramuscular injection of boldenone and focus on the role of Moringa oleifera as co-trateated substance in improving hepatic and renal toxicity of boldenone. 40 adult rats were equally divided into four main groups. Group A injected intramuscularly with olive oil, group B treated only with Moringa oleifera 200 mg/Kg body weight, group C injected with boldenone undecylenate only once every three weeks, and co-treated group D which received both intramuscular boldenone undecylenate once every three weeks beside intragastrically dose of of Moringa leaf extract twic-=0lie/week. The results showed that all the animals in the control groups (A and B) appeared healthy till the end of the experiment. The groups treated with boldenone showed a significant elevation in the levels of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total protein, urea, and creatinine compared to the control group. While the oxidative stress in the groups treated with boldenone showed a significant increase in the level of Malondialdehyde (MDA), nitric oxide (NO), total protein, and total thiol and marked reduction in the level of Glutathione (GSH), Catalase activity (CAT), superoxide dismutase activity (SOD). On the other hand the groups treated with Moringa olifera showed a marked reduction in the level of ALT, AST, urea, creatinine, MDA, and NO. While the level of GSH, CAT, and SOD showed a significant increase comparing with the control group. These results explain the side effect of boldenone undecylenate on the liver and kidney which may cause hepatic and renal diseases and also the role of Moringa olifera in improving these results.

DOI

10.21608/jbaar.2016.109494

Keywords

Boldenone, Moringa Olifera, Rats, kidney, Liver, steroids, Anabolic androgenic steroid

Authors

First Name

Ehab

Last Name

Tousson

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt

Email

toussonehab@yahoo.com

City

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Orcid

-

First Name

Ezar

Last Name

Hafez

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Masoud

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Reem

Last Name

Ashour

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

Omer

Last Name

Ershidot

MiddleName

-

Affiliation

Al-Balqa' Applied University, Irbid University College, Jordan

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-

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Volume

2

Article Issue

10

Related Issue

16640

Issue Date

2016-10-01

Receive Date

2016-09-12

Publish Date

2016-10-24

Page Start

686

Page End

694

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 10_Pages 686-694.pdf

PDF . 487.8kB

Link

https://jbaar.journals.ekb.eg/article_109494.html

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https://jbaar.journals.ekb.eg/service?article_code=109494

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4

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Modulation of boldenone induced hepatic and renal toxicity by Moringa oleiferaas in albino rats.

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Article

Created At

22 Jan 2023