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109491

Oral supplementation of aqueous Ginkgo biloba extract inhibits oxidative stress and hippocampus injury associated with methotrexate injection.

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Last updated: 25 Dec 2024

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Abstract

Methotrexate is effective for the treatment of a number of cancers including breast, lung, leukemia an osteosarcoma. This study was conducted to examine the possible modifying effects of Ginkgo biloba against hippocampal and brain toxicity induced by methotrexate in male albino rats. This could be fulfilled through the histological, immunohistochemically and biochemical analysis of hippocampal brain tissues. The experiments were performed on 36 male albino rats divided into 6 groups; the first and second groups were the control and Gingko groups respectively while the 3rd group methotrexate rat group; the 4th and the 5th groups were co- and post treated Methotrexate rat groups with Gingko respectively and the 6th group was methotrexate self-treated rat group. In brain homogenates Malondialdehyde (MDA) levels in methotrexate group showed a significant increase when compared with control group, in contrast methotrexate-treated group also exhibited a significant decrease in brain antioxidants machinery represented by catalase, reduced glutathione (GSH) and total proteins. The histological changes consisted of destruction of oligodendrocytes, sometimes complete over large areas, and sometimes relatively slight. All the rats which survived long enough after treatment showed severe astrocytosis. Rats' brains immunocytochemical results showed that GFAP-positive cells astrocytes increase after Exposure to (MTX) compared with the other groups.

DOI

10.21608/jbaar.2016.109491

Keywords

Hippocampus, Gingko biloba, Rats, Brain, Methotrexate

Authors

First Name

Ehab

Last Name

Tousson

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

toussonehab@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Masoud

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

First Name

Afaf M.

Last Name

Elatrsh

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

First Name

Tamer

Last Name

Mostafa

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

Volume

2

Article Issue

10

Related Issue

16640

Issue Date

2016-10-01

Receive Date

2016-09-25

Publish Date

2016-10-01

Page Start

651

Page End

660

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 10_Pages 651-660.pdf

PDF . 1.3MB

Link

https://jbaar.journals.ekb.eg/article_109491.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=109491

Order

2

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Oral supplementation of aqueous Ginkgo biloba extract inhibits oxidative stress and hippocampus injury associated with methotrexate injection.

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Article

Created At

22 Jan 2023