ManageChatDiscover
108933

Ameliorative effect of olive leaves extract on hepatotoxicity and oxidative stress in streptozotocin-induced diabetic rats.

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease. Olive leaves consists of phenolic compounds, flavonoids and volatile oil. The aim of this study was to evaluate the anti-diabetic and the curative effect of olive leaves extract on streptozotocin-induced diabetic rats. Forty male rats were divided into 4 groups, Group I; Animals were served as control. Group II; Animals were received oral Olive leaves extract (OLE) 0.5 mg/kg of body weight/day. Group III; Animals were injected intraperitoneally with a single dose of streptozotocin (STZ) (45mg /kg of body weight) to induce diabetes. Group IV, Animals were received a single dose of streptozotocin and after 7 days received Olive leaves extract for four weeks. The results indicatet that injection of STZ provoked a significant increase (P<0.005) in serum ALT, AST and lipids. Moreover, Serum malondialdehyde was increased and the antioxidant enzymes SOD and CAT decreased. Histopathologically, the OLE group didn't show any histopathological changes. Diabetic animals showed many histopathological changes in liver e.g. destruction of liver architecture, congestion of blood vessels, Leucocytic infiltration, and cytoplasmic vacuolization of hepatocytes. The pancreas showed severe damages in the pancreas architecture and atrophy of β-cells. When animals treated with OLE, an improvement was observed in the biochemical parameters and liver and pancreas histology of these animals. It is concluded that OLE exhibited a pronounced hypoglycemic, hypolipidemic and ameliorative effects in diabetic rats and this is may be attributed to the presence of its phenolic compounds.

DOI

10.21608/jbaar.2016.108933

Keywords

diabetes, Olive leaves, histopathology, liver rats, Oxidative Stress

Authors

First Name

Saber A.

Last Name

Sakr

MiddleName

-

Affiliation

Zoology Dep. Faculty of Science, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Karoline K.

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Zoology Dep. Faculty of Science, Damanhour University, Damanhour, Egypt

Email

-

City

-

Orcid

-

First Name

Attalla F.

Last Name

El-kott

MiddleName

-

Affiliation

Zoology Dep. Faculty of Science, Damanhour University, Damanhour, Egypt

Email

-

City

-

Orcid

-

First Name

Heba S.

Last Name

Khalifa

MiddleName

-

Affiliation

Zoology Dep. Faculty of Science, Damanhour University, Damanhour, Egypt

Email

-

City

-

Orcid

-

Volume

2

Article Issue

8

Related Issue

16486

Issue Date

2016-08-01

Receive Date

2016-07-15

Publish Date

2016-08-22

Page Start

549

Page End

560

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 8_Pages 549-560.pdf

PDF . 1.3MB

Link

https://jbaar.journals.ekb.eg/article_108933.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=108933

Order

3

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Ameliorative effect of olive leaves extract on hepatotoxicity and oxidative stress in streptozotocin-induced diabetic rats.

Details

Type

Article

Created At

22 Jan 2023