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108733

Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.

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Last updated: 25 Dec 2024

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Abstract

Viral hepatitis and infection with Schistosma mansoni are the main causes of chronic liver disease and liver cirrhosis. Infection with hepatitis C virus (HCV) is the most important public health problem in Egypt. This study was done to determine the association between Schistosma and hepatitis C, by testing liver function using the following biochemical tests: Total and direct bilirubin, TB-DB, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), serum albumin, and liver biopsy, and make comparison between them. The results indicated that 60 % of cases HCV and Bilharzias reveal abnormal results accompanied by chronic liver disease, when compared to the 40% of normal result. All cases were subjected to routine biochemical liver function tests and serum antibodies to bilharziasis. The results showed that, ALT and AST were highly significant difference in group hepatitis C only compared with control group which showed normal results. The other liver functions such as ALP, TB and DB were high in patients with hepatitis C and Biharziasis compared with control group with statically significant difference P<0.05 . Also, the results showed histopatholigical changes (fibrosis and cirrhosis) in patients with Hepatitis C and Hepatitis C and Biharziasis after taking liver biopsy from both patients.

DOI

10.21608/jbaar.2016.108733

Keywords

hepatitis C, Schistosoma mansoni, Liver function tests, histopathology, Co infection

Authors

First Name

Mahmoud Imam

Last Name

Nasr

MiddleName

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Affiliation

Molecular biology Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City

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Orcid

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First Name

Dalia Reda Mahmoud

Last Name

Hassan

MiddleName

-

Affiliation

Molecular biology Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City

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City

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Orcid

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First Name

Abd El-Moniem A. Younis

Last Name

Dawah

MiddleName

-

Affiliation

Public health and community medicine Dept., Faculty of Medicine, Benha University

Email

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City

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Orcid

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First Name

Alaa A.

Last Name

Hemeida

MiddleName

-

Affiliation

Bioinformatics Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City.

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City

-

Orcid

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First Name

Reham M.

Last Name

Abd El-Azeem

MiddleName

-

Affiliation

Environmental Biotechnology Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City

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City

-

Orcid

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Volume

2

Article Issue

7

Related Issue

16440

Issue Date

2016-07-01

Receive Date

2016-06-12

Publish Date

2016-07-21

Page Start

452

Page End

457

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 7_Pages 452-457.pdf

PDF . 451.1kB

Link

https://jbaar.journals.ekb.eg/article_108733.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=108733

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2

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.

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Article

Created At

22 Jan 2023