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108533

Protective effect of Coenzyme Q10 against gentamicin induced acute renal failure in mice.

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Last updated: 25 Dec 2024

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Abstract

Gentamicin is an antibiotic whose clinical use is limited by its nephrotoxicity. Coenzyme Q10 (CoQ10) is an effective antioxidant and used for therapy of a number of diseases. The present study was designed to investigate the possible protective effect of CoQ10 against gentamicin induced nephrotoxicity in mice. Thirty five adult male mice were used in this study and were randomly divided into five groups, each consisting of seven animals as follows: group I: normal control; group II: treated with CoQ10 (30 mg/kg/day, orally for 14 days); group III: treated with gentamicin (80 mg/kg/day, i.p. for 14 days); group IV: treated with CoQ10 and gentamicin for 14 days; group V: treated with gentamicin (80 mg/kg/day) i.p. for 14 days, after that the animals were given CoQ10 (30 mg/kg/day) orally for 7 days. At the end of the experiment, blood was collected and serum was separated for the estimation of serum creatinine and urea. Then the mice were sacrificed and kidneys were removed for histopathological study. The biochemical results showed that Coenzyme Q10 administration with gentamicin injections significantly decreased serum urea and creatinine when compared with gentamicin group. Light microscopic examination of the renal tissues from gentamicin-treated mice revealed severe histopathological changes, whereas specimens obtained from CoQ10 treated mice revealed only mild changes. Conclusion: It appears that CoQ10 has some protective role against gentamicin induced nephrotoxicity.

DOI

10.21608/jbaar.2016.108533

Keywords

gentamicin, Coenzyme Q10, Nephrotoxicity, histopathology, Mice

Authors

First Name

Abdel Razik H.

Last Name

Farrag

MiddleName

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Affiliation

Pathology Department, Medical Research Division, National Research Centre, Cairo, Egypt

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First Name

Rania A.

Last Name

Ibrahim

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Affiliation

Zoology Department, Faculty of Science, Suez University, Suez, Egypt.

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Orcid

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First Name

Shimaa N.

Last Name

El-Sayed

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Suez University, Suez, Egypt.

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Volume

2

Article Issue

6

Related Issue

16400

Issue Date

2016-06-01

Receive Date

2016-05-13

Publish Date

2016-06-26

Page Start

401

Page End

406

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 6_Pages 401-406.pdf

PDF . 631.9kB

Link

https://jbaar.journals.ekb.eg/article_108533.html

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https://jbaar.journals.ekb.eg/service?article_code=108533

Order

6

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Protective effect of Coenzyme Q10 against gentamicin induced acute renal failure in mice.

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Article

Created At

22 Jan 2023