Beta
ManageSearchChatDiscover
108375

Biochemical study of some non invasive markers in liver fibrosis patients.

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Non-invasive methods have been proposed as surrogate markers for liver biopsy. It was shown that serum hyaluronic acid (HA) level increase with the development of liver fibrosis. The present study aims to determine serum HA level cut-off points for predicting liver fibrosis. Serum HA level in chronic hepatitis patients (n=60) are divided into two groups, group1: included 30 patients, there were positive for anti-HCV (antibodies), group2: included 30 patients, there were positive for HBsAg, and controls (n=10) were assessed by ELISA and liver histopathological parameters were evaluated by the modified Knodell score and microscopic examination of liver biopsies. The results showed that individuals in healthy control group have normal levels of HA (mean 14.3, SD: 5.5) while the levels of HA were elevated in patients of HCV alone (mean 103.6±28.0) and in patient of HCV (mean 104.5± 37.5).Also levels of HA were poorly elevated in HBV alone (mean 62.2± 15.5) and in HBV (mean 45.8± 12.4).The comparison between the studied groups regarding to the level of HA showed that a significant difference was observed between healthy group and HBV & HCV groups (P < 0.001).HA levels and stages of fibrosis were well correlated in patients of HBV and HCV group. Where, this is a significant increase in HA levels when considering F0 to F6 scores by liver biopsy (P < 0.001). Serum HA levels are well correlated with HAI In patients Of HBV & HCV groups where, there was significant increase in HA levels by increase of HAI in liver biopsy at P < 0.001.

DOI

10.21608/jbaar.2016.108375

Keywords

Chronic hepatitis, Liver fibrosis, Hyaluronic acid, Liver Biopsy

Authors

First Name

Ayman E.

Last Name

El Agroudy

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed S.

Last Name

Elghareb

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

Email

-

City

-

Orcid

-

First Name

Tamer A.

Last Name

Addissouky

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

Email

-

City

-

Orcid

-

First Name

Emad H.

Last Name

Elshahat

MiddleName

-

Affiliation

Gastrointestinal Surgery Centre, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Ezar H.

Last Name

Hafez

MiddleName

-

Affiliation

Department Of Zoology, Faculty of Science, Tanta University, Tanta, Egypt

Email

-

City

-

Orcid

-

Volume

2

Article Issue

5

Related Issue

16343

Issue Date

2016-05-01

Receive Date

2016-04-18

Publish Date

2016-05-23

Page Start

319

Page End

325

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 5_Pages 319-325.pdf

PDF . 513.6kB

Link

https://jbaar.journals.ekb.eg/article_108375.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=108375

Order

4

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Biochemical study of some non invasive markers in liver fibrosis patients.

Details

Type

Article

Created At

22 Jan 2023