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106941

Ameliorative effect of ginger extract against pathological alterations induced in mice bearing solid tumors.

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Last updated: 04 Jan 2025

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Abstract

This study was prepared to explore the effect of ginger extract in defeating the Ehrlich Ascites Carcinoma (EAC) injected subcutaneously in mice and induced solid tumour. After the solid tumour formation; the mice were classified into four groups (control, tumour untreated, ginger and ginger & tumour). Eight mice were grouped separately in each cage. Mice were killed and dissected at the end of this investigation; liver and kidney were removed for histopathological study. The biochemical parameters (ALT, AST, Urea, Creatinine, MDA, SOD and CAT) were measured in the sera of all tested groups. Ginger extract ameliorated the histological structures of both liver and kidney to be near to control, modulated the elevated values of (ALT, AST, Urea, Creatinine and MDA) and reduced values of (SOD and CAT) to record slightly normal readings. Tumour volumes reduced significantly and the destructed genomic DNA retained the normal pattern. Ginger has no pathological effects on control mice.

DOI

10.21608/jbaar.2016.106941

Keywords

biochemistry, DNA pattern, Ginger, kidney, Liver, Mice, solid tumour

Authors

First Name

Osama M.

Last Name

Badr

MiddleName

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Affiliation

Animal Biotechnology Department, Genetic Engineering & Biotechnology Institute, Sadat City University , Sadat City, Menoufia Province, Egypt.

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First Name

Hala M.

Last Name

Abd-Eltawab

MiddleName

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Affiliation

Animal Biotechnology Department, Genetic Engineering & Biotechnology Institute, Sadat City University , Sadat City, Menoufia Province, Egypt.

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First Name

Saber A.

Last Name

Sakr

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Affiliation

Zoology Department, Faculty of Science, Menoufia University, Shebin Elkom, Menoufia Province, Egypt.

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Volume

2

Article Issue

3

Related Issue

16188

Issue Date

2016-03-01

Receive Date

2016-02-21

Publish Date

2016-03-01

Page Start

185

Page End

196

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 3_Pages 185-196.pdf

PDF . 954.3kB

Link

https://jbaar.journals.ekb.eg/article_106941.html

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https://jbaar.journals.ekb.eg/service?article_code=106941

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4

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Ameliorative effect of ginger extract against pathological alterations induced in mice bearing solid tumors.

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Article

Created At

22 Jan 2023