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106936

Effect of experimental phenylketonuria on some organs of pregnant mothers of albino rats and their young’s during perinatal life.

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Last updated: 25 Dec 2024

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Abstract

Phenylketonuria (PKU) is a genetic disorder that is characterized by an inability of the body to utilize the essential amino acid, phenylalanine.It results from a deficiency in phenylalanine hydroxylase, the enzyme catalyzing the conversion of phenylalanine to tyrosine. Although this inborn error of metabolism was among the first in humans to be understood biochemically and genetically, little is known about the mechanisms involved in the pathology of PKU during neonatal brain development. Elevated concentrations of plasma phenylalanine were induced in pregnant rats by oral administration of 50 mg/100 g body weight alpha-methylphenylalanine (to inhibit maternal liver phenylalanine hydroxylase) plus phenylalanine supplementation) at a dosage of 60 mg/100 g body weight two times daily (to increase maternal and fetal plasma phenylalanine) after 6th day of onset of gestation till 14 & 16 days of gestation as well as at parturition. Treatment with alpha-methylphenylalanine/phenylalanine resulted in significant decrease of accumulated body weight gain during pregnancy as well as exhibited marked growth retardation of prenatal feti and delivered newborn. Histological examination of maternal tissues including liver, heart, kidney & thyroid gland revealed varieties of histopathological abnormalities which illustrated and discussed. These results suggested that exposure of the fetus to high plasma concentrations of phenylalanine caused a delay in the biochemical maturation

DOI

10.21608/jbaar.2016.106936

Keywords

Phenylketonuria, pregnanat ,feteus,histological examination

Authors

First Name

Hassan. I.

Last Name

Elsayyad

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University

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Orcid

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First Name

Hany A.

Last Name

Hefny

MiddleName

-

Affiliation

Biology Department, University College, Um Al Qura University Al-jomoum,SA , Zoology Department, Faculty of Science ,Suez canal University

Email

-

City

-

Orcid

-

First Name

Mahmoud E.

Last Name

Mohallal

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Suez canal University

Email

-

City

-

Orcid

-

First Name

Hala . M.

Last Name

Ebied

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Suez canal University

Email

-

City

-

Orcid

-

Volume

2

Article Issue

3

Related Issue

16188

Issue Date

2016-03-01

Receive Date

2016-02-15

Publish Date

2016-03-01

Page Start

158

Page End

169

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 3_Pages 158-169.pdf

PDF . 1.7MB

Link

https://jbaar.journals.ekb.eg/article_106936.html

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https://jbaar.journals.ekb.eg/service?article_code=106936

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2

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Effect of experimental phenylketonuria on some organs of pregnant mothers of albino rats and their young’s during perinatal life.

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Article

Created At

22 Jan 2023