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106932

Nitric oxide level and CD3-ζ expression in response to Interferon- Ribavirin Therapy in chronic Hepatitis C Egyptian patients.

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Last updated: 25 Dec 2024

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Abstract

Hepatitis C virus (HCV) infection is one of the major causes of liver diseases all over the world; it is considered one of the leading causes of cirrhosis, hepatic failure and hepatocellular carcinoma (HCC) in developed countries including Egypt. Since, the discovery of the virus, the main drug used in all antiviral protocols was interferon- α (IFN- α) but, which is not effective in 60% of these patients. The goal of this study was to measure nitric oxide synthase (NOS), and CD3-ζ in chronic HCV patients which could explain the failure from therapy. 5ml of peripheral blood were collected from 30 patients with chronic HCV infection and 10 healthy control volunteers. Patients were categorized in to responders and non-responders according to viral titre upon IFN-α treatment. CD3-ζ expression was measured in the peripheral blood by using flow_cytomery and NOS levels were assessed in the sera. Significant decreases (P˂0.001) in the expression of CD3-ζ in IFN-α non- responder was recorded when compared to responder patients and with healthy volunteers. In contrast, there were significant increases (P˂0.001) in the expression of NOS in IFN-α responder as compared to non-responder patients and healthy volunteers. Conclusion: these findings can be suggestedNitric oxide level and CD3-ζ expressionthat have immune suppressive function can be reversed and enhance responsive of HCV patients to interferon- α and ribavirin.

DOI

10.21608/jbaar.2016.106932

Keywords

Hepatitis C Virus (HCV), IFN-α, Ribavirin, Nitric oxide synthesis (NOS), CD3 Zeta

Authors

First Name

M.L.

Last Name

Salem

MiddleName

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Affiliation

Immunology & Biotechnology Division, Department of Zoology,Faculty of Science; Tanta University; Egypt

Email

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City

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Orcid

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First Name

A.A.

Last Name

Zeidan

MiddleName

-

Affiliation

Immunology & Biotechnology Division, Department of Zoology,Faculty of Science; Tanta University; Egypt

Email

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City

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Orcid

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First Name

L.A.

Last Name

Barakat

MiddleName

-

Affiliation

Biochemistry Section, Department of Chemistry,Faculty of Science, Port Said University; Egypt

Email

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City

-

Orcid

-

First Name

N.A

Last Name

Elnakeeb

MiddleName

-

Affiliation

Biochemistry Section, Department of Chemistry,Faculty of Science, Port Said University; Egypt

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Orcid

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Volume

2

Article Issue

3

Related Issue

16188

Issue Date

2016-03-01

Receive Date

2016-02-15

Publish Date

2016-03-01

Page Start

151

Page End

157

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 3_Pages 151-157.pdf

PDF . 704.3kB

Link

https://jbaar.journals.ekb.eg/article_106932.html

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https://jbaar.journals.ekb.eg/service?article_code=106932

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Nitric oxide level and CD3-ζ expression in response to Interferon- Ribavirin Therapy in chronic Hepatitis C Egyptian patients.

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Article

Created At

22 Jan 2023