Beta
ManageSearchChatDiscover
107536

Effect of garlic on toluene-induced biochemical and histopathological effects in albino rats.

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The present study aims to study the effect of garlic extract on toluene inhalation at very low dose, induced hematological, biochemical and histological alterations in liver of albino rats. Animals were divided into 4 groups.Group 1 (G1) served ascontrols,G2 given garlic aqueous extract,G3 inhaled toluene vapor and G4 given garlic plusinhalation of toluene vapor. Animals were sacrificed after 2and 4weeks of treatment. The results showed that exposing animals to toluene induced significant decrease in red blood cell count (RBCs),hemoglobin (HGB),and blood platelets (PLT).On the other hand, the hematocrit percentage (HCT) and white blood cells(WBCs) count increased. Moreover, transaminases(ALT and AST) and gamma-glutamyl transferase (GGT) were increased in the sera of treated animals.Histological examination of liver of treated rats showed leukocytic infiltrations, congestion of blood vessels,cytoplasmic vacuolations of hepatocytes and fatty degeneration.Treated kidney in rats of G3 showed glomerular tufts congestion; renal space narrowing and epithelia of some renal tubules were degenerated with hemorrhage between them. To some extent, an improvement was observed in the kidney of the recovery group. Treating animals with garlic plus toluene caused an improvement in the biochemical and histological alterations in albino rats.It could be concluded that the protective effect of garlic may be attributed to the presence of organosulfur compounds which have antioxidant and detoxifying properties.

DOI

10.21608/jbaar.2016.107536

Keywords

Toluene, Garlic, Liver, kidney, Rats, hematology, transaminases

Authors

First Name

Zuhair Y.

Last Name

Al-Sahhaf

MiddleName

-

Affiliation

Department of Biology, Faculty of Applied Sciences, Umm Al-Qura University, Makkah,Saudi Arabia.

Email

-

City

-

Orcid

-

First Name

Osama M.

Last Name

Sarhan

MiddleName

-

Affiliation

Department of Biology, Faculty of Applied Sciences, Umm Al-Qura University, Makkah,Saudi Arabia. , Department of Zoology, Faculty of Science, Fayoum University, Fayoum, Egypt.

Email

-

City

-

Orcid

-

Volume

2

Article Issue

4

Related Issue

16281

Issue Date

2016-04-01

Receive Date

2016-03-16

Publish Date

2016-04-22

Page Start

250

Page End

257

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 4_Pages 250-257.pdf

PDF . 779.1kB

Link

https://jbaar.journals.ekb.eg/article_107536.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=107536

Order

3

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Effect of garlic on toluene-induced biochemical and histopathological effects in albino rats.

Details

Type

Article

Created At

22 Jan 2023