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107535

Pre-eclampsia – An excessive maternal immune response in Egyption wommen.

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Last updated: 25 Dec 2024

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Abstract

Preeclampsia is a stressful condition in which many physiological and metabolic functions are altered to a considerable extent.Although pre eclampsia causes high maternal /fetal morbidity, the etiology of this multisystem disorder is still unknown. We have detected the cytokine levels inpreeclamptic women compared to normotensive pregnant and non-pregnant women.This study aimed to understand immunological network , and physiological parameters for the pathogeneses of preeclampsia.Serum levels of tumor necrosis factor alpha (TNFα ) and interleukin 10(IL-10 )were measured by enzyme-linked immunosorbent assay (ELISA) . C reactive protein (CRP) was evaluated as inflammatory marker in preeclampsia.Our findings demonstrated that pre eclamptic state is associated with high levels of pro inflammatory cytokine TNFα (p < 0.05) and C.R.P. By contrast, normotensive pregnancy evolved high levels of regulatory cytokine Il-10 .The present study supports the hypothesis of altered immune response in preeclampsia.

DOI

10.21608/jbaar.2016.107535

Keywords

C-Reactive protein (CRP), pro inflammatory cytokine(TNFα ), regulatory cytokine (IL-10 )

Authors

First Name

Maha G.

Last Name

Soliman

MiddleName

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Affiliation

Zoology Department, Faculty of Science , (girls), Al- Azhar University

Email

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City

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Orcid

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First Name

Mervat

Last Name

Abd El Alim

MiddleName

-

Affiliation

Zoology Department, Faculty of Science , (girls), Al- Azhar University

Email

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City

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Orcid

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First Name

Ayaa A.

Last Name

Shoaip

MiddleName

-

Affiliation

Zoology Department, Faculty of Science , (girls), Al- Azhar University

Email

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City

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Orcid

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First Name

Abd El-Hady A.

Last Name

Zayed

MiddleName

-

Affiliation

Faculty of Medicine, Mansoura University,Egypt

Email

-

City

-

Orcid

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Volume

2

Article Issue

4

Related Issue

16281

Issue Date

2016-04-01

Receive Date

2016-03-15

Publish Date

2016-04-21

Page Start

244

Page End

249

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 4_Pages 244-249.pdf

PDF . 257.2kB

Link

https://jbaar.journals.ekb.eg/article_107535.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=107535

Order

2

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Pre-eclampsia – An excessive maternal immune response in Egyption wommen.

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Article

Created At

22 Jan 2023