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107534

Effect of experimental phenylketonuria on the development of skin of prenatel and newborn fetuses.

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Last updated: 25 Dec 2024

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Abstract

Phenylketonuria (PKU) is a genetic disorder that is characterized by an inability of the body to utilize the essential amino acid, phenylalanine. The disease results from a deficiency in phenylalanine hydroxylase, the enzyme catalyzing the conversion of phenylalanine to tyrosine. The present work studied the Effect of experimental phenylketonuria on the development of skin of prenatel and newborn fetuses.The disease was induced in pregnant rats by daily intragastric administration of 30 mg. DL-a-methylphenylalanine/kg body weight plus 60 mg/kg body weight at 12 h intervals throughout pregnancy till parturition. Treatment with alpha-methylphenylalanine/phenylalanine resulted in significant decrease of accumulated body weight gain during pregnancy as well as exhibited marked growth retardation of prenatal fetuses and delivered newborn. The growth retarded fetuses was manifested by decreased body weight, malformed both fore -& hind limb, oedematous skin & superficial hematomas widely spreads in different parts of the body. Vibrissae skin hair were characterized by curved free ends as well as reduction of their size and length. Cornification was retarded . The epidermis attained a considerable thinning with delayed differentiation of epidermal cell layers.The growing hair follicles lacked normal characteristic appearance. These results suggested that exposure of the fetus to high plasma concentrations of phenylalanine caused a delay in the biochemical maturation of the fetal rat.

DOI

10.21608/jbaar.2016.107534

Keywords

Phenylketonuria, Rats, skin, gestation, Newborn

Authors

First Name

Hassan.I.

Last Name

Elsayyad

MiddleName

-

Affiliation

Zoology Department, Faculty of Science , Mansoura University

Email

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Orcid

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First Name

Mahmoud. E.

Last Name

Mohallal

MiddleName

-

Affiliation

Zoology Department, Faculty of Science ,Suez canal University

Email

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City

-

Orcid

-

First Name

Hany .A .

Last Name

Hefny

MiddleName

-

Affiliation

Zoology Department, Faculty of Science ,Suez canal University , Biology Department, University College, Um Al Qura University Al-jomoum,SA.

Email

-

City

-

Orcid

-

First Name

Hala . M.

Last Name

Ebied

MiddleName

-

Affiliation

Zoology Department, Faculty of Science ,Suez canal University

Email

-

City

-

Orcid

-

Volume

2

Article Issue

4

Related Issue

16281

Issue Date

2016-04-01

Receive Date

2016-03-15

Publish Date

2016-04-20

Page Start

233

Page End

243

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 4_Pages 233-243.pdf

PDF . 1.1MB

Link

https://jbaar.journals.ekb.eg/article_107534.html

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https://jbaar.journals.ekb.eg/service?article_code=107534

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Effect of experimental phenylketonuria on the development of skin of prenatel and newborn fetuses.

Details

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Article

Created At

22 Jan 2023