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106918

Assessment of the hazard effect of an environmental pollutant, (2-OH-BDE 123) using zebrafish embryos.

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Last updated: 25 Dec 2024

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Abstract

In the recent decades, many environmental pollutants have received significant attention due to their potential ability to mimic the actions of endogenous estrogens. These pollutants are referred as environmental estrogens and are suspected of causing health effects in both humans and wildlife through disruption of the endocrine system and causing male reproductive dysfunction, thus they are classified as endocrine disrupting compounds (EDCs) such as phenolic metabolites. To monitor general toxicity of this class of EDCs, embryos of zebrafish were exposed to gradual concentrations of 2-OH-BDE 123 (hydroxy-brominated diphenyl ethers). Exposures were done by immersion of 1 hour post fertilization (hpf) zebrafish eggs to 72 hpf, nominal concentration range of 0.03 : 2.5 μM. Embryos/ larvae were assessed daily for death and structural defects. Results revealed that concentrations from 0.3 μM of such metabolites were toxic to the developing zebrafish causing serious morphological alterations and internal deformations. Both toxicity incidence and potency were correlated with the concentration applied. In conclusion, these compounds induced several teratogenic effects. More studies are required for a proper risk assessment and more attention should be given to this class of chemicals in the aquatic environment.

DOI

10.21608/jbaar.2016.106918

Keywords

pollutant, toxicity, zebrafish, developmental abnormality, teratogenicity

Authors

First Name

Nessrin A.

Last Name

Kheirallah

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Alexandria University, Egypt , College of Sciences and Humanity Studies P. O. Box 83, Alkharj 11942, Prince Sattam bin Abdulaziz University, Kingdom of Saudi Arabia.

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First Name

Tamer El-Sayed.

Last Name

Ali

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-

Affiliation

Oceanography Department, Faculty of Science, Alexandria University, Egypt. , College of Sciences and Humanity Studies P. O. Box 83, Alkharj 11942, Prince Sattam bin Abdulaziz University, Kingdom of Saudi Arabia.

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Volume

2

Article Issue

2

Related Issue

16119

Issue Date

2016-02-01

Receive Date

2016-01-21

Publish Date

2016-02-01

Page Start

136

Page End

141

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 2_Pages 136-141.pdf

PDF . 467.2kB

Link

https://jbaar.journals.ekb.eg/article_106918.html

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https://jbaar.journals.ekb.eg/service?article_code=106918

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7

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Assessment of the hazard effect of an environmental pollutant, (2-OH-BDE 123) using zebrafish embryos.

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Article

Created At

22 Jan 2023