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106914

Some biochemical markers and expression of indoleamine-2, 3-dioxygenase in Egyptian patients with chronic Hepatitis C.

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Last updated: 25 Dec 2024

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Abstract

Hepatitis C virus (HCV) is a main cause of chronic hepatitis and it may leads to cirrhosis, hepatic failure and hepatocellular carcinoma. Chronic HCV patients are subjected to treatment with ribavirin and interferon-α (IFN-α) but,which have achieved only limited success. The main aim of this study was to measure indoleamine-2, 3-dioxygenase (IDO) in chronic HCV patients which could explain the failure from therapy. Five ml of peripheral blood were collected from 30 patients with chronic HCV infection and 10 healthy control volunteers. Patients were categorized in to responders and non-responders according to viral titre upon IFN-α treatment. The levels of IDO were measured in the sera of the recruited subjects. Significant increases (P˂0.001) in the concentration of IDO were observed in IFN-α non-responder patient when compared with responders and healthy control. Conclusion: Non-responsiveness of chronic HCV patients to IFNs based therapy associated with increases in suppressive mechanisms, opening a new avenue for targeting these molecules in HCV therapy.

DOI

10.21608/jbaar.2016.106914

Keywords

Hepatitis C Virus (HCV), Immune suppression, IFN-α, Ribavirin, Indoleamine 2, 3- dioxygenase (IDO)

Authors

First Name

M.L.

Last Name

Salem

MiddleName

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Affiliation

Immunology & Biotechnology Division, Department of Zoology,Faculty of Science; Tanta University; Egypt

Email

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City

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Orcid

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First Name

A.A.

Last Name

Zeidan

MiddleName

-

Affiliation

Immunology & Biotechnology Division, Department of Zoology,Faculty of Science; Tanta University; Egypt

Email

-

City

-

Orcid

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First Name

L.A.

Last Name

Barakat

MiddleName

-

Affiliation

Biochemistry Section, Department of Chemistry,Faculty of Science, Port Said University; Egypt

Email

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City

-

Orcid

-

First Name

N.A

Last Name

Elnakeeb

MiddleName

-

Affiliation

Biochemistry Section, Department of Chemistry,Faculty of Science, Port Said University; Egypt

Email

-

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

16119

Issue Date

2016-02-01

Receive Date

2016-01-20

Publish Date

2016-02-01

Page Start

118

Page End

124

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 2_Pages 118-124.pdf

PDF . 708.7kB

Link

https://jbaar.journals.ekb.eg/article_106914.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=106914

Order

5

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Some biochemical markers and expression of indoleamine-2, 3-dioxygenase in Egyptian patients with chronic Hepatitis C.

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Article

Created At

22 Jan 2023