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106913

Comparative cardioprotective effect of Egyptian Silybum marianum extract and Chinese silymarin in experimentally liver fibrosis.

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Last updated: 25 Dec 2024

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Abstract

Liver fibrosis is one of the common problems effects on the human health. Many herbal, medicinal and pharmaceutical plants and their extracts are widely studied by many researches. Chinese silymarin got a bright reputation in relieve of liver fibrosis. The current study is a comparative study between the effect of Chinese silymarin (commercial drug) and the extracted silymarin from the natural Egyptian plant on the cardiac toxicity due to liver fibrosis induced by ethanol in rats. A total of 72 female Albino rats were divided into six groups; G1, Control; G2,Fibrosis; G3,Chinese silymarin; G4, Fibrosis + Chinese silymarin; G5, Egyptian silymarin extract; G6, Fibrosis + Egyptian silymarin extract. Results showed that, heart enzymes activities LDH, lipid profiles in serum and MDA in tissues were a significant increase in Fibrosis group when compared with control group. On the other hand; creatine kinase (CK) in serum, total protein, total thiol, TAC, CAT and GST in cardiac tissues were a significant decrease in Fibrosis group when compared with control group. The current results revealed that; the Egyptian plant extract improved the lipid profile, heart functions and its oxidative stress parameters as comparison with the used medical Chinese silymarin.

DOI

10.21608/jbaar.2016.106913

Keywords

ethanol, Milk thistle extract, Silymarin, heart, Oxidative Stress, p53

Authors

First Name

Ehab

Last Name

Tousson

MiddleName

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Affiliation

Department of Zoology, Faculty of Science, Tanta University, Egypt.

Email

toussonehab@yahoo.com

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First Name

Afrah F.

Last Name

Salama

MiddleName

-

Affiliation

Biochemistry Section, Department of Chemistry, Faculty of Science, Tanta University, Egypt.

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Orcid

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First Name

Mona A.

Last Name

Dora

MiddleName

-

Affiliation

Biochemistry Section, Department of Chemistry, Faculty of Science, Tanta University, Egypt.

Email

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City

-

Orcid

-

First Name

Mahmoud A.

Last Name

Elony

MiddleName

-

Affiliation

Botany Department, Faculty of Science, Tanta University, Egypt

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-

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-

Orcid

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Volume

2

Article Issue

2

Related Issue

16119

Issue Date

2016-02-01

Receive Date

2016-01-18

Publish Date

2016-02-01

Page Start

107

Page End

117

Print ISSN

2356-9174

Online ISSN

2356-9182

Link

https://jbaar.journals.ekb.eg/article_106913.html

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https://jbaar.journals.ekb.eg/service?article_code=106913

Order

4

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Comparative cardioprotective effect of Egyptian Silybum marianum extract and Chinese silymarin in experimentally liver fibrosis.

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Article

Created At

22 Jan 2023