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106488

Potential hepatoprotection exerted by ginseng against chlorpyrifos-induced hepatotoxicity in albino rats.

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Last updated: 25 Dec 2024

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Abstract

Insecticides gained public reputation and widespread application to control the spread of different insects in various habitats. However, the deleterious effects of these chemicals could not be ignored and should be dealt seriously. The present work was conducted to test the efficacy of the natural plant ginseng in alleviating toxicity of chlorpyrifos. The organophosphorus insecticide chlorpyrifos induced hepatotoxicity and changes in some serum biochemical parameters. The liver of rats administered chlorpyrifos manifested cytoplasmic vacuolization, leucocytic infiltration, hemorrhage and remarkable dilatation of veins. The nuclear chromatin was condensed. There was a significant increase in alanin aminotransferase (ALT) while there was a significant decrease in albumin, catalase (CAT) and superoxide dismutase (SOD) in the serum of treated rats. Treating animals with ginseng was found in this study to alleviate hepatotoxicity and restore the levels of the tested serum parameters to nearly normal values.

DOI

10.21608/jbaar.2016.106488

Keywords

chlorpyrifos, Rats, Liver, histology, Ginseng, ALT, albumin, antioxidants

Authors

First Name

M.F.F.

Last Name

Bayomy

MiddleName

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Affiliation

Dept.of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

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Orcid

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First Name

H. A.

Last Name

Abdel Samie

MiddleName

-

Affiliation

Dept.of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

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City

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Orcid

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First Name

S.E. M.

Last Name

Gendia

MiddleName

-

Affiliation

Dept.of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

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Orcid

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Volume

2

Article Issue

1

Related Issue

16116

Issue Date

2016-01-01

Receive Date

2015-12-24

Publish Date

2016-01-01

Page Start

51

Page End

63

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 1_Pages 51-63.pdf

PDF . 551.2kB

Link

https://jbaar.journals.ekb.eg/article_106488.html

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https://jbaar.journals.ekb.eg/service?article_code=106488

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6

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Potential hepatoprotection exerted by ginseng against chlorpyrifos-induced hepatotoxicity in albino rats.

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Article

Created At

22 Jan 2023