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106483

Ameliorating effect of propolis and moringa extract against equigan induced neurotoxicity and oxidative stress on rat hippocampus.

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Last updated: 25 Dec 2024

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Abstract

In most countries worldwide, Equigan is anabolic steroid that is forbidden for human uses or for meat production. The present study was designed to investigate the ameliorating role of Propolis and moringa leaf extract (MLE) against Equigan induced neurotoxicity and oxidative stress on rat hippocampus. A total of 48 healthy male albino rats weighing 170-200 g and of 10-12 weeks age were divided into 6 groups (8 animals each). 1st Control group includes animals that injected intramuscularly with olive oil for 12 weeks. 2nd and 3rd groups were rats received Propolis and MLE respectively. 4th experimental group include animals that receive intramuscular injections of Equigan for 12 weeks; 5th and 6th groups where rats intramuscular injected with Equigan and treated with Propolis and MLE at the same time respectively. The obtained results indicate that hippocampal nitric oxide (NO), malondialdehyde (MDA), acetylcholine esterase (AChE) and total protein were significantly increased in Equigan group when compared with control group. In contrast hippocampal catalase, SOD and total thiol levels were significantly decreased in Equigan group when compared with control group. On the other hand hippocampal NO, MDA, ACE and total protein in Equigan group were significantly increased when compared with co-treated Equigan with MLE or Propolis groups. In contrast; hippocampal catalase, SOD and total thiol levels were significantly decreased in Equigan group when compared with co-treated Equigan with MLE or propolis groups. We can concluded that; MLE and propolis extract ameliorate the neurotoxicity and oxidative stress on rat hippocampus induces by Equigan.

DOI

10.21608/jbaar.2016.106483

Keywords

Steroid hormones, Equigan, Moringa oleifera, Propolis, Hippocampus, Oxidative Stress

Authors

First Name

Ehab

Last Name

Tousson

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

toussonehab@yahoo.com

City

-

Orcid

-

First Name

Ezar

Last Name

Hafez

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Massoud

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Elfeky

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

16116

Issue Date

2016-01-01

Receive Date

2015-12-25

Publish Date

2016-01-01

Page Start

30

Page End

37

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 1_Pages 30-37.pdf

PDF . 653.9kB

Link

https://jbaar.journals.ekb.eg/article_106483.html

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https://jbaar.journals.ekb.eg/service?article_code=106483

Order

3

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Ameliorating effect of propolis and moringa extract against equigan induced neurotoxicity and oxidative stress on rat hippocampus.

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Type

Article

Created At

22 Jan 2023