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106481

Gasoline induced pulmo- oxidative damage in mice model

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Last updated: 25 Dec 2024

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Abstract

The present work aims to evaluatethe cytotoxic effects on lung cells exerted by gasoline. 60 male albino mice were used in the present experiment, divided equally into 3 groups: first group (control) was left access to fresh air, second group (experimental) was subjected to gasoline 80- vapor/1h./day and third group (experimental) was subjected to gasoline 90-vapor/1h./day along eight consecutive weeks. The study comprises determination of body weight, bioaccumulation of some heavy metals ,histological and ultra-changes . Histological changes increased according to duration of exposure as, infiltration of inflammatory cells, detachment and necrosis of the epithelial cells .The electron micrographs revealed dilatation of the smooth endoplasmic reticulum, loss of the secretory granules in the Clara cells and loss of cilia in the ciliated cells that exhibited bleb formation. Necrotic type II pneumocytes, exhibited vacuolation, fragmentation of the rough endoplasmic reticulum,mitochondrial degeneration , nuclear alterations, degeneration of lamellar bodies and microvillar atrophy. In conclusion, gasoline vapour inhalation induced lung tissue injury and cellular damage concomitant with impairment of the lung antioxidant defense system. These effects were more pronounced with the unleaded than with the leaded gasoline.

DOI

10.21608/jbaar.2016.106481

Keywords

gasoline, Mice Model, bioaccumulation, body weight, histology

Authors

First Name

Awatef

Last Name

Ali

MiddleName

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Affiliation

Zoology department –Faculty of Science –Alexandria University-Egypt

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Orcid

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First Name

Nawal

Last Name

El-Ghazaly

MiddleName

-

Affiliation

Zoology department –Faculty of Science –Alexandria University-Egypt

Email

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Orcid

-

First Name

Samir

Last Name

Dekinesh

MiddleName

-

Affiliation

Zoology department –Faculty of Science –Alexandria University-Egypt

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City

-

Orcid

-

First Name

Azza

Last Name

Sedky

MiddleName

-

Affiliation

Zoology department –Faculty of Science –Alexandria University-Egypt

Email

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City

-

Orcid

-

First Name

Sanaa

Last Name

Kabiel

MiddleName

-

Affiliation

Genetic &Biotechnology institute-City of Scientific Researches-Alexandria University- Egypt

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Volume

2

Article Issue

1

Related Issue

16116

Issue Date

2016-01-01

Receive Date

2015-12-20

Publish Date

2016-01-01

Page Start

1

Page End

9

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 2_Issue 1_Pages 1-9.pdf

PDF . 482.7kB

Link

https://jbaar.journals.ekb.eg/article_106481.html

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https://jbaar.journals.ekb.eg/service?article_code=106481

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Gasoline induced pulmo- oxidative damage in mice model

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Article

Created At

22 Jan 2023