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106037

Effects of L-carnitine and Ginkgo bilobaon cerebral cortex in experimentally-induced epileptic seizures disease in rat

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Last updated: 04 Jan 2025

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Abstract

Pentylenetetrazole (PTZ) kindling is an acknowledged model for epilepsy and refers to a phenomenon in which repeated injection of this drug causes a gradual seizure. The current study aimed to determine the possible protective and ameliorative effects of L-carnitine and Ginkgo Biloba leaf extracts (GLE) against PTZinduced epileptic seizures disease in rats. A total of 80 male albino rats were equally divided into eight groups; 1st group was the control; 2nd and 3rd wereGLE and L-carnitine groups, respectively; while the 4th group was pentylenetetrazolerat group and the 5th and 6th groups were pre GLE and L-carnitine groups respectively; the 7th and 8th groups were post GLE and L-carnitine, respectively. PTZ leads to an increase in malondialdehyde (MDA), glutamate (Glu) and to a decrease in catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) activity, glutathione reductase(GSH), gamma amino butyric acid (GABA) and acetylcholine esterase (AChE) in the cerebral cortex of rats when compared to control group. Pre- and post treatment with GLE and L-carnitine were improved the biochemicalalterations in the cerebral cortex that treated with PTZ.

DOI

10.21608/jbaar.2015.106037

Keywords

pentylenetetrazole, Epilepsy, Seizures, cerebral cortex, Ginkgo biloba, L-carnitine, Oxidative Stress, EZR-ir

Authors

First Name

Ehab

Last Name

Tousson

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Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt.

Email

toussonehab@yahoo.com

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First Name

Mohamed F.F

Last Name

Bayomy

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Menoufiya University, Egypt

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Orcid

-

First Name

Basiouny Fouad

Last Name

El-sendiony

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Menoufiya University, Egypt

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Orcid

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Volume

1

Article Issue

6

Related Issue

16046

Issue Date

2015-12-01

Receive Date

2015-11-10

Publish Date

2015-12-01

Page Start

277

Page End

289

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 1_Issue 6_Pages 277-289.pdf

PDF . 1.1MB

Link

https://jbaar.journals.ekb.eg/article_106037.html

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https://jbaar.journals.ekb.eg/service?article_code=106037

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4

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Effects of L-carnitine and Ginkgo bilobaon cerebral cortex in experimentally-induced epileptic seizures disease in rat

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Article

Created At

22 Jan 2023