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106032

Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

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Last updated: 25 Dec 2024

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Abstract

Apoptosis plays a critical role in the development and homeostasis of multicellular organisms, especially those with high cell turnover such as the lymphoid system. The current study aimed to examined the effects of changes in thyroid hormones on apoptosis of spleen in male rats. 30 rats were equally divided into three groups (10 animals each). G1, control group in which animals did not received any treatment; G2, Hypothyroid group in which rats received 0.05% 6-n-propyl-2-thiouracil (PTU) in drinking water for 6 weeks; G3, Hyperthyroid group in which rats received 100 μg/Kg L-Thyroxin sodium administration in drinking water for 6 weeks. In the present study; serum T3 and T4 concentrations were depressed and serum TSH concentration was significantly elevated in rats receiving PTU-induced hypothyroidism. On the other hand; serum T3 and T4 concentrations were significantly elevated and serum TSH concentration was depressed in rats receiving L-Thyroxin sodium-induced hyperthyroidism. In the current study; spleen in both hypothyroid and hyperthyroid rats revealed many of abnormalities as marked disruption of spleen structure, loss in distinction between the white and red pulps, degeneration and vacuolation with an increased in the lymphocyte population. Also, a significant increase in p53 and Caspase3 apoptotic cells and a significant decrease in Bcl-2 antiapoptotic cells in the spleen tissues revealed the possibility of the apoptosis occurrence after PTU or Thyroxin administration in the case of hypothyroidism and hyperthyroidism.

DOI

10.21608/jbaar.2015.106032

Keywords

hypothyroidism, Hyperthyroidism, Rats, kidney, Liver, testes, spleen, heart

Authors

First Name

Ezar

Last Name

Hafez

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

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City

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Orcid

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First Name

Ahmed

Last Name

Masoud

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

First Name

Magdy

Last Name

Barnous

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

-

City

-

Orcid

-

First Name

Ehab

Last Name

Tousson

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Email

toussonehab@yahoo.com

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-

Orcid

-

Volume

1

Article Issue

5

Related Issue

16045

Issue Date

2015-11-01

Receive Date

2015-10-15

Publish Date

2015-11-01

Page Start

234

Page End

242

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 1_Issue 5_Pages 234-242.pdf

PDF . 422.3kB

Link

https://jbaar.journals.ekb.eg/article_106032.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=106032

Order

5

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

Details

Type

Article

Created At

22 Jan 2023