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Hemoglobin A2 Cut off Values in Egyptian Cohort as a marker of β -Thalassemia carriers.

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Last updated: 25 Dec 2024

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Abstract

Beta thalassemias (β-thalassemias) are a group of inherited blood disorders caused by reduced or absent synthesis of beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated 1 in 100.000 throughout the world. HbA2 determination plays a key role in screening programs for β-thalassemia since a small increase in this fraction is the most important marker of β-thalassemia heterozygous carriers. This study aims to detect the cut off value of Hb A2 in Egyptian individuals with β-thalassemia and microcytic hypochromic anemia, using automated HPLC. The study was carried out on 112 male and female cases. Their ages ranged from 2 years to 35 years. They were 28 normal cases, 20 cases diagnosed as microcytic hypochromic anemia, 52 cases as β-thalassemia trait and 12 cases as β-thalassemia intermedia. Informed consents were obtained from their care givers. CBC was done to all groups and HbA2 levels were measured using HPLC Bio- Rad D-10 dual program (β-thal short program) for identification of types of Hb and determining the cut off value of Hb A2. The Hb A2 cut off value in microcytic hypochromic anemia cases was >2.2%, in β-thalassemia intermedia cases was >3.2% and in β-thalassemia trait cases was >3.6% which showed the best cut off value, and hence the cut off value of Hb A2 could be used as a factor that plays a key role in screening programs for β- thalassemia carriers.

DOI

10.21608/jbaar.2015.106021

Keywords

β-thalassmia carriers, HbA2 cut off

Authors

First Name

Noura

Last Name

Kablan

MiddleName

M.

Affiliation

Department of Molecular Diagnostics and Therapeutics, Genetic Engineering and Biotechnology Research Institute, University of Sadat City.

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Orcid

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First Name

Manal

Last Name

El Hamshary

MiddleName

O.

Affiliation

Department of Molecular Diagnostics and Therapeutics, Genetic Engineering and Biotechnology Research Institute, University of Sadat City.

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

Nasr

MiddleName

M.

Affiliation

Department of Molecular Diagnostics and Therapeutics, Genetic Engineering and Biotechnology Research Institute, University of Sadat City.

Email

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City

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Orcid

-

First Name

Mohamed

Last Name

Hamza

MiddleName

T.

Affiliation

Department of Clinical pathology, Faculty of Medicine, Ain Shams University

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City

-

Orcid

-

First Name

Tarif

Last Name

Salam

MiddleName

H.

Affiliation

Department of Clinical pathology, Faculty of Medicine, Ain Shams University

Email

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City

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Orcid

-

First Name

Alaa

Last Name

Hemeida

MiddleName

A.

Affiliation

Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt

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City

-

Orcid

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Volume

1

Article Issue

4

Related Issue

16044

Issue Date

2015-10-01

Receive Date

2015-09-10

Publish Date

2015-10-01

Page Start

154

Page End

159

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 1_Issue 4_Pages 154-159.pdf

PDF . 231.5kB

Link

https://jbaar.journals.ekb.eg/article_106021.html

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https://jbaar.journals.ekb.eg/service?article_code=106021

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2

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Hemoglobin A2 Cut off Values in Egyptian Cohort as a marker of β -Thalassemia carriers.

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Article

Created At

22 Jan 2023