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105961

Effects of swine flu (H1N1) vaccine on albino rats

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Last updated: 04 Jan 2025

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Abstract

The pandemic flu (2009) is a global outbreak of a new strain of H1N1 influenza virus that referred as “swine flu". The 2009 flu pandemic vaccines (H1N1 vaccines) are the biological preparation of influenza vaccines that have been developed to protect and improve immunity against the pandemic H1N1/09 virus. Squalene has been added to vaccine as immunologic adjuvant to stimulate the immune system, increase the response to the vaccine and reduce amount of usage vaccine. Thimerosal has been added to some vaccines as a preservative because it is effective in preventing bacterial contamination, particularly in multidose containers. To investigate the possible immunological effects of swine flu vaccine, Albino rats were injected with H1N1 antigen contained thimerosal, adjuvant and H1N1 vaccine. Results obtained in the present study showed that squalene and thimerosal contributed to the regiment of adverse reactions and symptoms, which act as detergents instead of its helper role of vaccine that undergone toxicity effectors in the biological pathways including; immunopathological and histopathological effects; the damage was done by vaccine, particularly when potentiated by powerful “immunoenhancers" caused a strong immunostimulation that emphasized by results of this research as well as its biological hazards which are more pronounced when act together as whole vaccine than they act individually so the adverse events that resulted from treatment with squalene-adjuvanted vaccine are more potent than those of either antigen or squalene- treated groups

DOI

10.21608/jbaar.2015.105961

Keywords

H1N1, squalene, vaccine

Authors

First Name

Fatma

Last Name

Eid

MiddleName

Ahmed

Affiliation

Department of Zoology, Faculty of Science, Al- Azhar University, Cairo, Egypt

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First Name

Alya

Last Name

Aly

MiddleName

Mohammed

Affiliation

Department of Zoology, Faculty of Science, Al- Azhar University, Cairo, Egypt

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Orcid

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First Name

Nadia

Last Name

Ibrahim

MiddleName

Fathy

Affiliation

Department of Zoology, Faculty of Science, Al- Azhar University, Cairo, Egypt

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City

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Orcid

-

First Name

Aly

Last Name

Mohamed

MiddleName

Fahmy

Affiliation

The Holding Company for Biological Products and Vaccines (EGYVAC-VACSERA), Dokki, Giza, Egypt

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Volume

1

Article Issue

3

Related Issue

16036

Issue Date

2015-09-01

Receive Date

2015-08-08

Publish Date

2015-09-01

Page Start

121

Page End

126

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 1_Issue 3_Pages 121-126.pdf

PDF . 546.9kB

Link

https://jbaar.journals.ekb.eg/article_105961.html

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https://jbaar.journals.ekb.eg/service?article_code=105961

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4

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Effects of swine flu (H1N1) vaccine on albino rats

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Article

Created At

22 Jan 2023