This work aims to study the histopathological and histochemical changes in the testes of male albino rats post exposure to mobile phone radiation and the possible protective role of vitamin E and/or silymarin. The current experiment was carried out on 30 adult male albino rats (Sprague dawly). Rats were randomly and equally divided into five groups: 1) Group C: control rats left without treatment; 2) Group R: rats exposed to frequency equals 950 MHz of electromagnetic field (EMF); 3) Group R + E: rats received vitamin E before exposure to frequency equals 950 MHz of EMF; 4) Group R + S: rats received silymarin before exposure to frequency equals 950 MHz of EMF and 5) Group R + E+ S: rats received vitamin E parallel to silymarin before exposure to frequency equals 950 MHz of EMF. Electromagnetic field exposed rats showed testicular alterations which were ameliorated by using either vitamin E or silymarin alone. However, both vitamin E and silymarin administration ameliorated the damaging effects of testes of mobile phone exposed rats more than that of silymarin or vitamin E alone