Beta
ManageSearchChatDiscover
105950

Clomiphene citrate induced kidney injury in female albino rat

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Clomiphene citrate (clomid), a selective oestrogen-receptor modulator, is used in the treatment of polycystic ovary syndrome. On the other hand, it showed many adverse effects. The present work investigates the effects of clomiphene citrate (CC) on kidney of female albino rats. Many biochemical and histological changes were induced in these animals when treated with CC at doses of 50 and 100 mg/kg body weight. Treating animals with doses of 50 and 100 mg/kg body weight caused elevations in serum creatinine and urea. The histological changes in the kidney of treated animals included intertubular leucocytic infiltrations, congestion of blood vessels and degeneration of renal tubules. Moreover, atrophy of glomeruli was recorded. In conclusion, biochemical and histopathological alterations indicated that clomiphene citrate causes renal damage in female albino rats

DOI

10.21608/jbaar.2015.105950

Keywords

biochemistry, Clomiphene citrate, histology, kidney, Rats

Authors

First Name

Hawazen

Last Name

Lamfon

MiddleName

A.

Affiliation

Biology Department, Faculty of Applied Science, Umm Al- Qura University, Makkah, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Nahid

Last Name

Lamfon

MiddleName

A.

Affiliation

Consultant Family &Community Medicine, King Abullaziz medical City / National Guard Health Affair / Riyadh

Email

-

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

16035

Issue Date

2015-06-01

Receive Date

2015-04-25

Publish Date

2015-06-01

Page Start

39

Page End

43

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 1_Issue 2_Pages 39-43.pdf

PDF . 8.7MB

Link

https://jbaar.journals.ekb.eg/article_105950.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=105950

Order

1

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Clomiphene citrate induced kidney injury in female albino rat

Details

Type

Article

Created At

22 Jan 2023