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105945

Ameliorative effect of aqueous extract of rosemary on cadmium-induced kidney injury in albino rats

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Last updated: 04 Jan 2025

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Abstract

Cadmium (Cd) is one of the heavy metals causing risks for living organisms and induced high toxicity to the different biological systems. Rosemary (Rosemarinus Officinalis) is a plant widely used in food. It has antimicrobial, antioxidant, anti-carcinogenic properties. The present work studied the effect of rosemary leaf extract on Cd-induced kidney injury in rats. Cadmium chloride (30 mg/kg b.w, 5 consecutive days/week for 8 weeks) administration increased renal MDA but decreased GSH, CAT, and SOD activities versus control. In parallel, serum urea and creatinine increased. Cadmium chloride caused histological alternations involved shrinkage in glomeruli, congestion in blood vessels, dilation in renal tubules, and leucocytic infiltrations. Ultrastructural observations showed an abnormality in the nucleus, endoplasmic reticulum, brush border, proximal and distal convoluted tubules. On the contrary, the administration of aqueous extract of rosemary restored these changes. The results suggested that rosemary ameliorative these changes due to its antioxidant properties by scavenging free radicals resulting from cadmium chloride.

DOI

10.21608/jbaar.2015.105945

Authors

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A.

Last Name

El-Morsy

MiddleName

M.

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First Name

S.

Last Name

Sakr

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A.

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First Name

M.

Last Name

Bayomy

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F

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Volume

1

Article Issue

1

Related Issue

16033

Issue Date

2015-03-01

Receive Date

2015-02-22

Publish Date

2015-03-01

Page Start

10

Page End

19

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 1_Issue 1_Pages 10-19.pdf

PDF . 19.6MB

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https://jbaar.journals.ekb.eg/article_105945.html

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https://jbaar.journals.ekb.eg/service?article_code=105945

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1,272

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Publication Title

Journal of Bioscience and Applied Research

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https://jbaar.journals.ekb.eg/

MainTitle

Ameliorative effect of aqueous extract of rosemary on cadmium-induced kidney injury in albino rats

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Article

Created At

22 Jan 2023