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105944

Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats

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Last updated: 04 Jan 2025

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Abstract

Carbon tetrachloride (CCl4) is a known potent hepatotoxic agent. The present investigation clarified the ameliorative effects of Atacand and Gervital on CCl hepatotoxicity. 24 male albino rats were divided into 4 groups, 6 rats each. Group I, served as normal control. Group II, animals were injected subcutaneously with CCl (1ml/kg b.w.) twice a week for 90 days. Group III, rats were injected with CCl4, as Group II, then treated orally with Atacand (8mg/kg b.w.), daily, for 30 days. rats were injected with the same dose of CCl then treated with Atacand (8mg/kg b.w.) along with Gervital (100mg/kg b.w.), orally, daily for 30 days. treatment showed a marked deterioration of liver function as a high increase in the levels of serum AST and ALT (153.8% and 157.8%, respectively). Also, a significant decrease in liver antioxidant machinery was represented by reduced glutathione (GSH, 68.1%), glutathione transferase (GST, 69.9%), and glutathione reductase (GR, 65.65%). On the other side, the levels of liver protein carbonyl groups (PCO) and lipid peroxidation (LPO) were elevated 439.6% and 258.7%, respectively, compared to their control groups. These results indicated the damage as a result of CCl4-induced liver fibrosis. Both treatments with Atacand or Atacand + Gervital showed a significant ameliorative effect for both liver and serum CCl4-induced alterations. The current study recorded the treatment with Gervital along with Atacand antifibrotic effectiveness than that of Atacand Gervital acted as a potentiator for the antifibrotic activity of Atacand.

DOI

10.21608/jbaar.2015.105944

Keywords

Atacand, Carbon tetrachloride, Gervital, liver function, Oxidative Stress

Authors

First Name

Faten

Last Name

Abdel- Ghaffar

MiddleName

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Affiliation

Department of Zoology, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt

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Orcid

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First Name

Ibrahim

Last Name

El-Elaimy

MiddleName

A.

Affiliation

Department of Zoology, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt

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-

City

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Orcid

-

First Name

Mona

Last Name

EL. Ghreeb

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt

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-

City

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Orcid

-

First Name

Azza

Last Name

Mohamed

MiddleName

M.

Affiliation

Department of Therapeutic Chemistry, National Research Center, Dokki. Egypt

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-

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-

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-

Volume

1

Article Issue

1

Related Issue

16033

Issue Date

2015-03-01

Receive Date

2015-02-10

Publish Date

2015-03-01

Page Start

1

Page End

9

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 1_Issue 1_Pages 1-9.pdf

PDF . 5.3MB

Link

https://jbaar.journals.ekb.eg/article_105944.html

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https://jbaar.journals.ekb.eg/service?article_code=105944

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Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats

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Article

Created At

22 Jan 2023