The Greater Cairo (GC) is one of the largest urban clusters in the world. Basiclly, it contains three interlocked cities including Cairo City (the capital). In the last two decades, many new suburbs were constructed to the east of the old Cairo City. The current study investigates recent urbanization of the new suburbs and its impacts on natural landscape-geomorphology. A series of optical satellite images are utilized to quantify land-cover changes from 2000 to 2017. Detailed field studies were carried out. These field studies allow checking remotely sensed data and observing human-induced landforms. The human activities (urban growth) alter the native geomorphology, mainly drainage basins (wadis). Two applied case studies have been carried out. These applied case studies probe the flash flood risk in the New Cairo City and the New Adminstrative Capital, and demonstrate the land subsidence in Madinty suburb.