Fifteen healthy adult experimental donkeys weighted about (150 - 200 kg) were used in this study. These Animals were housed in Surgery Clinic of Mansoura Veteri nary Teaching Hospital and were premedicated intravenously with xylazine Hcl (1.1mg/1cg). In addition, eighteen animals (9 horses and 9 donkeys) anesthetizedfora variety of clinical surgical procedures. Five minutes later, anesthesia was induced and maintained with one of the following combinations. Xylazine Hcl (0.5 mg/ ml), guaifen e,sin (50 mg/ ml) and 1cetamine Hcl (2 mg/ ml) in 1 liter of warm dextrose 5% (group I), xylazine Hcl (0.5 mg/ ml), guaifenesin (50 mg/ ml) and thiopental sodium (4 mg/ ml) in 1 liter of warm dextrose 5% (group II) and xylazine Hcl (0.5 mg/ ml), midazolam (0.04 mg/ml) and 1cetamine Hcl (2 mg/ml) in 1 liter of dextrose 5% (group III). The anesthetic quality (induction, degree of analgesia, muscle relaxation, sedation and quality of re covery), cardiopulmonary effects, hematology, blood chemistry and blood gases were estimated in all groups. All compared anesthetic protocols showed smooth induction. The quality of sedation, analgesia and muscle relaxation in XGK and XMK groups were good to excellent. The quality of recovery was smooth and good to excellent in XGK and XMK groups, while it was moderate in XGT group. All compared anesthetic protocols are suitable to induce and maintairi appropriate safe state of anesthesia under field conditions in equidae