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177932

EFFECTS OF THE NONSTEROIDAL ECDYSONE AGONIST, TEBUFENOZIDE, ON LIVER CYP ACTIVITIES

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Last updated: 04 Jan 2025

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Tags

Pharmacology and toxicology

Abstract

The non-steroidal ecdysone agonist tebufenozide was orally administered to Wistar rats for 5 days to examine their effects on the liver cytochrome P450 (CYP) activities. Also Michaelis-Menten kinetics of the metabolic reactions catalyzed by liver CYPs were studied after adding tebufenozide to the assay system to investigate its possible inhibitory effects on liver CYPs activities. These reactions included ethoxyresorufin O-deethylation, tolbutamide hydroxylation, bufuralol 1-hydroxylation, and midazolam 1,4-hydroxylation, for CYP1A, 2C, 2D, and 3A activities, respectively. Results revealed no any significant alteration in the activities of the tested microsomal enzymes after oral administration of tebufenozide. none of the examined CYPs was inhibited by tebufenozide as the Ki values were very high (more than 9000 M). We can conclude that tebufenozide is considered safe and can be a good alternate for the traditional insecticides.

DOI

10.21608/mvmj.2014.177932

Authors

First Name

Rania

Last Name

Abdou

MiddleName

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Affiliation

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Email

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Orcid

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Volume

16

Article Issue

1

Related Issue

25739

Issue Date

2014-06-01

Receive Date

2021-06-15

Publish Date

2014-06-01

Page Start

369

Page End

383

Print ISSN

1110-7219

Online ISSN

2682-2512

Article File

MVMJ_Volume 16_Issue 1_Pages 369-383.pdf

PDF . 519.8kB

Link

https://mvmj.journals.ekb.eg/article_177932.html

Detail API

https://mvmj.journals.ekb.eg/service?article_code=177932

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1

Type

Original Articles

Type Code

1,268

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

Publication Link

https://mvmj.journals.ekb.eg/

MainTitle

EFFECTS OF THE NONSTEROIDAL ECDYSONE AGONIST, TEBUFENOZIDE, ON LIVER CYP ACTIVITIES

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Type

Article

Created At

22 Jan 2023