This field study was carried - out on 3200 Barky sheep of different farm and of age raged from four month to five years age . These farms has a history of nervous manifestation such as hyperexcitability, hyperethesia , nystagmus, unilateral blinding and deviation of the head either to lest or to right, in coordination, ataxia and depression and other respiratory signs as snoring, Rhinitis and sneezing. On P.M lesions was done after death and after slaughtering found thin walled cysts up to 5 m present in the brain especially on external surface of the cerebral hemisphere and other cyst present in cerebrum under horn and containe white fluid and cassation, the tissue surrounding the cysts was necrotic and pusiated , in other sheep found Larvae in frontal sinus and may in brain with abscess formation . Treatment of diseased sheep occur by given 30 sheep paraziruantil 25 mg / kg for week ( Albendazol - Pharmasweedes - Ltd , Egypt) 4 casees only was cured but the rest not responded also give ivermectin 1 m / 50 kg B.WT. in 20 cases, Butox 0.5% drop in nose in 10 cases , Nitroxynil 1 cm / 25 kg s/c in 10 cases and cure rate ware 3,8 and 2 respectively so the control of nervous manifestation in sheep of parasitic origin must depend on protection of sheep during summer season, fly insect proof stable , repellent on muzzle , fly insect proof stable and control of stray dogs, Administration of Ivermectin 1 ml /50 kg BWT every three month.