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Mesenchymal stem cells ameliorate ischemia reperfusion induced acute kidney injury in rat model

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Last updated: 04 Jan 2025

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Surgery

Abstract

Mesenchymal stem cells (MSCs) have generated a great deal of excitement and promise as a potential source of all types of cells for cell-based therapeutic strategies. The present study aimed to evaluate the ameliorative effect of MSCs injected via tail vein and sub-capsular in rats with ischemia reperfusion induced acute kidney injury. A total number of 72 Sprague dawely rats were used in this study and were divided into 3 groups: group (I): Negative control (n=18), group (II): ischemic reperfusion untreated ;(n=18) and group (III): ischemic reperfusion treated with MSCs (36 rats). group (III) was divided into two sub-groups : the first subgroup was treated with MSCs injected via tail vein;(n=18) and the second one was treated with MSCs injected subcapsular;(n=18) . six rats from each group and sub groups were euthanized at day1, days3, and day7 from beginning of the experimental study.for histopathological examination and Biochemical analysis was performed for serum creatinine, blood urea nitrogen (BUN), urine creatinine, kidney malondialdehyde (MDA), nitric oxide (NO).additionally to kidney injury lesion scores for kidneys tissue were performed in all experimental groups.Results of this study revealed that MSCs which injected sub-capsular in rats with ischemic reperfused acute renal injury induced ameliorative effects at day 7 through significant decreasing of serum creatinine, BUN, renal MDA, NO, renal fibrosis score and significantly increases creatinine clearance compared to rat sub-group treated with MSCs injected via tail vein.It was concluded that subcapsular injected MSCs in rats with ischemic reperfused ARI induced ameliorative effectcompared to tail vein injected MSCs in rats.

DOI

10.21608/mvmj.2019.22.101

Keywords

Mesenchymal Stem Cells, Ischemia - reperfusion, kidney, rat

Authors

First Name

Basma

Last Name

Othman

MiddleName

-

Affiliation

Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Egypt

Email

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City

-

Orcid

-

First Name

Esam

Last Name

Mosbah

MiddleName

-

Affiliation

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Sobh

MiddleName

-

Affiliation

Department of Nephrology & Urology, Faculty of Medicine, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Adel

Last Name

Zaghloul

MiddleName

-

Affiliation

-

Email

zagloladel@yahoo.com

City

-

Orcid

-

Volume

20

Article Issue

2

Related Issue

22627

Issue Date

2019-06-01

Receive Date

2019-02-25

Publish Date

2019-06-01

Page Start

1

Page End

5

Print ISSN

1110-7219

Online ISSN

2682-2512

Article File

MVMJ_Volume 20_Issue 2_Pages 1-5.pdf

PDF . 680.4kB

Link

https://mvmj.journals.ekb.eg/article_185436.html

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https://mvmj.journals.ekb.eg/service?article_code=185436

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10

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Original Articles

Type Code

1,268

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

Publication Link

https://mvmj.journals.ekb.eg/

MainTitle

Mesenchymal stem cells ameliorate ischemia reperfusion induced acute kidney injury in rat model

Details

Type

Article

Created At

22 Jan 2023