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154071

Pharmacokinetic studies on Sulfamonomethoxine in rabbits

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Pharmacology and toxicology

Abstract

The present study was performed to determine the pharmacokinetics of sulfamonomethoxine (20mg/kg) in 5 rabbits after its oral and intravenous administration. Blood samples were collected immediately before (time 0) and at 0.08, 0.25, 0.5, 1, 3, 5 and 8 hours post-dosing to evaluate the pharmacokinetics of sulfamonomethoxine. Plasma sulfamonomethoxine concentrations were quantified with HPLC-UV, and plasma drug concentration versus time data after IV was best fitted to the two-compartment model, CHARacterized with the distribution phase (α) equaled to 2.05 h-1 with a distribution half-life [t0.5(α)] equaled to 0.61 h. The volume of distribution of (V1c) was 0.15 ml/kg., whereas the volume of distribution at a steady – state [Vdss] was 0.20 ml/kg, and the body clearance was 0.03 ml/ kg / h. After oral administration of SMM, plasma drug concentrations were best fitted to a two-compartment model, of which the mean half-life of absorption (t1/2ab) and elimination (t1/2β) were 0.02 and 1.99 h, respectively. The maximal absorption concentration (Cmax) was estimated as 114.06 µg/ml at 0.12 h, and the Area under the curve (AUC) was 340.42 µg/ml/h.

DOI

10.21608/mvmj.2019.22.110

Keywords

Rabbits, sulfamonomethoxine

Authors

First Name

Magdy

Last Name

Amer

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Mansoura University

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Elsayed

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Mansoura University

Email

-

City

-

Orcid

-

First Name

S

Last Name

Kazawaki

MiddleName

-

Affiliation

Pharmacology Department, Tokyo University of Agriculture and Technology

Email

-

City

-

Orcid

-

First Name

W

Last Name

Fathy

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

El-Ashry

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Mansoura University

Email

dr_emansaleh@mans.edu.eg

City

-

Orcid

0000-0001-7129-7815

Volume

20

Article Issue

2

Related Issue

22627

Issue Date

2019-06-01

Receive Date

2019-04-06

Publish Date

2019-06-30

Page Start

58

Page End

63

Print ISSN

1110-7219

Online ISSN

2682-2512

Article File

MVMJ_Volume 20_Issue 2_Pages 58-63.pdf

PDF . 979.5kB

Link

https://mvmj.journals.ekb.eg/article_154071.html

Detail API

https://mvmj.journals.ekb.eg/service?article_code=154071

Order

2

Type

Original Articles

Type Code

1,268

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

Publication Link

https://mvmj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023