Subjects
-Tags
Pharmacology and toxicology
Abstract
present study aimed to investigate the prophylactic effect of Cymbopogon proximus and Alhagi maurorum on Sulfadimidine induced urolithiasis in rabbits . Thirty New Zealand male rabbits were allocated into six equal groups( each of five): Group(1) was used as a negative control. Group(2) were administered sulfadimidine (200mg/kg) by intramuscular injection.Groups(3) and (4) were administered sulfadimidine(200mg/kg) by intramuscular injection and 330mg/kg of Cymbopogon proximus alcoholic and aqueous extracts respectively orally.Groups(5) and (6) were administered sulfadimidine(200mg/kg) by intramuscular injection and 400mg/kg of Alhagi maurorum alcoholic and aqueous extracts respectively orally. The period of experiment was 10 days . Blood and urine samples were collected from rabbits on the 10th day. The results recorded a significant decrease in serum creatinine, urea, uric acid and crystalluria in Cymbopogon proximus and Alhagi maurorum groups compared to sulfadimidine treated group.We conclude that Cymbopogon proximus and Alhagi maurorum have a nephroprotective and antiurolithiatic effects against sulfadimidine induced crystalluria.
DOI
10.21608/mvmj.2019.01.107
Keywords
sulfadimidine, Cymbopogon proximus, Alhagi maurorum, Crystalluria, Rabbit
Authors
MiddleName
-Affiliation
Departments of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt
Email
-City
-Orcid
-MiddleName
-Affiliation
-Email
-City
-Orcid
-MiddleName
-Affiliation
-Email
-City
-Orcid
-MiddleName
-Affiliation
-Email
-City
-Orcid
-Link
https://mvmj.journals.ekb.eg/article_185599.html
Detail API
https://mvmj.journals.ekb.eg/service?article_code=185599
Publication Title
Mansoura Veterinary Medical Journal
Publication Link
https://mvmj.journals.ekb.eg/
MainTitle
Antiurolithiatic effect of Cymbopogon Proximus, Alhagi Maurorum, on Sulfadimidine induced urolithiasis in male New Zealand rabbits