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129838

THE PROTECTIVE EFFECT OF FUCOIDAN, BROWN ALGAE EXTRACT, AGAINST ACETAMINOPHEN HEPATOTOXICITY IN RAT

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Last updated: 22 Jan 2023

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Abstract

Forty male Sprague-Dawley rats were equally divided randomly into four groups to asses the protective effect of fucoidan against Acetaminophen induced hepatotoxicity. Elevated serum enzymes, mid-zonal vacuolar degeneration or steatosis, necrosis, hepatitis, calcified ,Cup shaped mitochondria and glycogen depletion were noticed in rats were intraperitoneal injected (IP) with (800mg/ kg. B.wt.). Fucoidan administration prior and simultaneously with acetaminophen ameliorated the induced hepatopathy. It lowered the serum enzymes and malondialdehyde (MDA) formation. In conclusion, our finding proved that fucoidan administration prior and simultaneous acetaminophen toxicity induced protective effects against hepatic damage through scavenging oxidative stressors and reduced lipid peroxidation.

DOI

10.21608/mvmj.2016.129838

Keywords

Fucoidan, BROWN ALGAE EXTRACT, ACETAMINOPHEN HEPATOTOXICITY, Rats

Authors

First Name

Ahmed E.

Last Name

Elnaggar

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First Name

Hussein S.

Last Name

Hussein

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First Name

Ahmed Shawky I.

Last Name

Abd- Elmaksoud

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Volume

17

Article Issue

2

Related Issue

19229

Issue Date

2016-06-01

Receive Date

2016-04-14

Publish Date

2016-07-01

Page Start

357

Page End

371

Print ISSN

1110-7219

Online ISSN

2682-2512

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https://mvmj.journals.ekb.eg/article_129838.html

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https://mvmj.journals.ekb.eg/service?article_code=129838

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33

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

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https://mvmj.journals.ekb.eg/

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Article

Created At

22 Jan 2023