In this study, we investigate the protective and therapeutic effect of Pentoxifylline
against liver damage induced by CCl4 in Guinea pigs by monitoring the hepatic m-RNA
expression of TGFβ-1, ,some serum biochemical parameters and some oxidative stress
biomarker. The CCl4 was orally administrated at dose 1 ml/kg bw twice a week for 8 weeks.
Pentoxifylline orally administrated at a dose rate at dose 20 mg/kg bw/day. We found that
Pentoxifylline treatment improved elevated m-RNA expression of TGFβ-1, ALT, T.Bil,
D.Bil, MDA and SOD serum levels induced by CCl4 at 8th week post treatment. Meanwhile,
AST and AP are not improved by Pentoxifylline treatment. Finally,We concluded that
pentoxifylline is to somewhat effective in down regulation of chronic liver injury induced by
CCl4 if used as protective treatment.