This study was carried out on forty female Spargue-DaLwley rats. Animals were divided into four equal groups (ten rats each). The first group (CAl was considered a control adult female rat two months age and was feed on basal ration without feed addtives. The other three groups were cortsidered aged animals (one year old), The second group was considered a control aged group (CAG) feed on basal ration without feed addilives.The third group (LA) was feed on basal ration supplemented with L-arginine (1.68%) and the fourth group (LC) was feed on: basal ration supplemented with L,carnttine (0.5 mg%) for four weeks. After the end of tile experiment, blood samples were collected from all the animal under experimental period (four weeks) for analysts of estradiol. hpid profile and malondialdehyde, antioxidant enzymatic activities (SOD and catalase) and reduced glutathione (GSH}. Tissue samples {ovary, kidney and liver were also Collected at the end of experiment for histopathological examination.